{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:03:11Z","timestamp":1794045791904,"version":"4.8.0"},"reference-count":231,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>The hypermobile type of Ehlers\u2013Danlos syndrome (hEDS) is likely the most common hereditary disorder of connective tissue. It has been described largely in those with musculoskeletal complaints including joint hypermobility, joint subluxations\/dislocations, as well as skin and soft tissue manifestations. Many patients report activity\u2010related pain and some go on to have daily pain. Two undifferentiated syndromes have been used to describe these manifestations\u2014joint hypermobility syndrome and hEDS. Both are clinical diagnoses in the absence of other causation. Current medical literature further complicates differentiation and describes multiple associated symptoms and disorders. The current EDS nosology combines these two entities into the hypermobile type of EDS. Herein, we review and summarize the literature as a better clinical description of this type of connective tissue disorder. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.c.31538","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T06:54:34Z","timestamp":1485932074000},"page":"48-69","source":"Crossref","is-referenced-by-count":474,"title":["Hypermobile Ehlers\u2013Danlos syndrome (a.k.a. Ehlers\u2013Danlos syndrome Type III and Ehlers\u2013Danlos syndrome hypermobility type): Clinical description and natural 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