{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:09:44Z","timestamp":1790456984478,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Chronic fatigue is an important contributor to impaired health\u2010related quality of life in Ehlers\u2013Danlos syndrome. There is overlap in the symptoms and findings of EDS and chronic fatigue syndrome. A proportion of those with CFS likely have EDS that has not been identified. The evaluation of chronic fatigue in EDS needs to include a careful clinical examination and laboratory testing to exclude common causes of fatigue including anemia, hypothyroidisim, and chronic infection, as well as dysfunction of major physiological or organ systems. Other problems that commonly contribute to fatigue in EDS include sleep disorders, chronic pain, deconditioning, cardiovascular autonomic dysfunction, bowel and bladder dysfunction, psychological issues, and nutritional deficiencies. While there is no specific pharmacological treatment for fatigue, many medications are effective for specific symptoms (such as headache, menstrual dysfunction, or myalgia) and for co\u2010morbid conditions that result in fatigue, including orthostatic intolerance and insomnia. Comprehensive treatment of fatigue needs to also evaluate for biomechanical problems that are common in EDS, and usually involves skilled physical therapy and attention to methods to prevent deconditioning. In addition to managing specific symptoms, treatment of fatigue in EDS also needs to focus on maintaining function and providing social, physical, and nutritional support, as well as providing on\u2010going medical evaluation of new problems and review of new evidence about proposed treatments. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.c.31542","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T13:28:42Z","timestamp":1486733322000},"page":"175-180","source":"Crossref","is-referenced-by-count":112,"title":["Chronic fatigue in Ehlers\u2013Danlos syndrome\u2014Hypermobile type"],"prefix":"10.1002","volume":"175","author":[{"given":"Alan","family":"Hakim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"De Wandele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"O'Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Pocinki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1993.tb01070.x"},{"key":"e_1_2_11_3_1","first-page":"597","article-title":"Chronic fatigue syndrome is commonly diagnosed in patients with Ehlers\u2010Danlos syndrome hypermobility type\/joint hypermobility syndrome","volume":"29","author":"Castori M","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35483"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2012.06.018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/580460"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew032"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh279"},{"key":"e_1_2_11_9_1","volume-title":"Beyond Myalgic Encephalomyelitis\/Chronic Fatigue syndrome: Redefining an illness","year":"2015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36293"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70173-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.02.015"},{"key":"e_1_2_11_13_1","volume-title":"Evidence Report\/Technology Assessment No. 219. 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