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Within the multidisciplinary team, physical therapy plays a central role in management of individuals with hypermobility related disorders. However, many physical therapists are not familiar with the diagnostic criteria, prevalence, common clinical presentation, and management. This guideline aims to provide practitioners with the state of the art regarding the assessment and management of children, adolescents, and adults with JHS\/hEDS. Due to the complexity of the symptoms in the profile of JHS\/hEDS, the International Classification of Functioning, Disability and Health (ICF) is adopted as a central framework whereby the umbrella term of disability is used to encompass functions, activities and participation, as well as environmental and personal factors. The current evidence\u2010based literature regarding the management of JHS\/hEDS is limited in size and quality and there is insufficient research exploring the clinical outcomes of a number of interventions. Multicenter randomized controlled trials are warranted to assess the clinical and cost\u2010effectiveness of interventions for children and adults. Until further multicenter trials are conducted, clinical decision\u2010making should be based on theoretical and the current limited research evidence. For all individuals diagnosed with JHS\/hEDS, international consensus and combined efforts to identify risk profiles would create a better understanding of the pathological mechanisms and the potential for optimizing health care for affected individuals. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.c.31545","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T14:05:37Z","timestamp":1489759537000},"page":"158-167","source":"Crossref","is-referenced-by-count":149,"title":["The evidence\u2010based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome\/hypermobile Ehlers Danlos syndrome"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6923-8696","authenticated-orcid":false,"given":"Raoul H.H.","family":"Engelbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-8415","authenticated-orcid":false,"given":"Birgit","family":"Juul\u2010Kristensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verity","family":"Pacey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"de Wandele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Smeenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoleta","family":"Woinarosky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Sabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Scheper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Russek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane V.","family":"Simmonds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.030"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh557"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20090226"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36060"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.5.413"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_6_9_1","first-page":"33","article-title":"Knowledge and perceptions of joint hypermobility syndrome amongst pediatric physiotherapists","volume":"36","author":"Billings S","year":"2015","journal-title":"J Physiother Pract Res"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1055"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070104"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0922-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.12968\/ijtr.2014.21.2.60"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/msc.184"},{"key":"e_1_2_6_15_1","first-page":"43","article-title":"A Study exploring the prevalence of Hypermobility Syndrome in a musculoskeletal triage clinic","volume":"36","author":"Connelly E","year":"2015","journal-title":"Physiother Res Pract"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000091643.35118.d3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2012.01858.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.12.006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1758"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.3.e248"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2219"},{"key":"e_1_2_6_22_1","first-page":"69","article-title":"A Cochrane review of the evidence for non\u2010surgical interventions for flexible pediatric flat feet","volume":"47","author":"Evans AM","year":"2011","journal-title":"Eur J Phys Rehabil Med"},{"key":"e_1_2_6_23_1","unstructured":"Evidence based Care Guideline for Management of Pediatric Joint Hypermobility Guideline Copyright \u00a92014. 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