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Abnormalities in neural crest\u2010derived tissues contribute to the etiology of CHARGE syndrome, a complex malformation disorder that encompasses clinical symptoms like coloboma, heart defects, atresia of the choanae, retarded growth and development, genital hypoplasia, ear anomalies, and deafness. Mutations in the chromodomain helicase DNA\u2010binding protein 7 (<jats:italic>CHD7<\/jats:italic>) gene are causative of CHARGE syndrome and loss\u2010of\u2010function data in different model systems have firmly established a role of CHD7 in neural crest development. 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