{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:27:42Z","timestamp":1759048062631,"version":"3.40.5"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Short stature is the most ubiquitous feature of Turner syndrome (TS). Today, many girls with TS are treated with recombinant human growth hormone (GH) to accelerate growth in childhood and to improve adult height. Here, we will review the history of our understanding of growth in TS, reflect on the path of clinical trials ultimately leading to regulatory approval for clinical use of GH, discuss factors associated with growth outcomes and survey the current unanswered questions about growth and GH in TS.<\/jats:p>","DOI":"10.1002\/ajmg.c.31680","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T22:50:55Z","timestamp":1551307855000},"page":"74-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Growth and growth hormone in Turner syndrome: Looking back, looking ahead"],"prefix":"10.1002","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7567-0178","authenticated-orcid":false,"given":"Evan","family":"Los","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Endocrinology East Tennessee State University  Johnson City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron G.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University  Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1222"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1999.12.5.623"},{"issue":"359","key":"e_1_2_9_4_1","first-page":"365","article-title":"Fatal degenerative neurologic disease in patients who received pituitary\u2010derived human growth hormone","volume":"34","author":"Center for Disease Control","year":"1985","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12231"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199411000-00005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2874"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000058376"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr030"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.11.5516"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(94)90223-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0430"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.09.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.3.607"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.08.060"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1997.10.1.27"},{"key":"e_1_2_9_17_1","first-page":"162","article-title":"Long\u2010acting growth hormone preparations in the treatment of children","volume":"16","author":"Lal R. A.","year":"2018","journal-title":"Pediatric Endocrinology Reviews"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439334"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.60.10.932"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.049817"},{"key":"e_1_2_9_21_1","first-page":"457","article-title":"Short stature in children with coeliac disease","volume":"6","author":"Meazza C.","year":"2009","journal-title":"Pediatric Endocrinology Reviews"},{"key":"e_1_2_9_22_1","first-page":"1289","article-title":"SHOX haploinsufficiency and its modifying factors","volume":"15","author":"Ogata T.","year":"2002","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2005.tb02081.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.2033"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4518"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80273-6"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000184154"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.11.4212"},{"key":"e_1_2_9_29_1","first-page":"111","article-title":"Somatotropin in the treatment of growth hormone deficiency and Turner syndrome in pediatric patients: A review","volume":"2","author":"Reh C. S.","year":"2010","journal-title":"Clinical Pharmacology"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.5.1936"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803103181003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.6.Supple10_45"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70452-4"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82540-5"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80272-4"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80290-7"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005669"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80349-0"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-017-0665-3"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.12.4607"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196410082711502"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2187"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1120130"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.46.250.745"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-23-5-566"},{"key":"e_1_2_9_46_1","first-page":"1110","article-title":"Final height in girls with Turner syndrome after long\u2010term growth hormone treatment in three dosages and low dose estrogens","volume":"88","author":"Pareren Y. K.","year":"2003","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2007.20.5.607"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000317529"}],"container-title":["American Journal of Medical Genetics Part C: Seminars in Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.c.31680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.c.31680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.c.31680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.c.31680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:56:39Z","timestamp":1694429799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.c.31680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/ajmg.c.31680"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.c.31680","archive":["Portico"],"relation":{},"ISSN":["1552-4868","1552-4876"],"issn-type":[{"type":"print","value":"1552-4868"},{"type":"electronic","value":"1552-4876"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2018-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}