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A definition of AMC was recently developed using a modified Delphi consensus method involving 25 experts in the field of AMC from 8 countries. Participants included health care professionals, researchers, and individuals with AMC. An annotation of the definition provides more in\u2010depth explanations of the different sentences of the AMC definition and is useful to complement the proposed definition. The aim of this study was to provide an annotation of the proposed consensus\u2010based AMC definition. For the annotation process, 17 experts in AMC representing 10 disciplines across 7 countries participated. A paragraph was developed for each sentence of the definition using an iterative process involving multiple authors with varied and complementary expertise, ensuring all points of view were taken into consideration. The annotated definition provides an overview of the different topics related to AMC and is intended for all stakeholders, including youth and adults with AMC, their families, and clinicians and researchers, with the hopes of unifying the understanding of AMC in the international community.<\/jats:p>","DOI":"10.1002\/ajmg.c.31721","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T01:33:17Z","timestamp":1562549597000},"page":"288-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["International multidisciplinary collaboration toward an annotated definition of arthrogryposis multiplex congenita"],"prefix":"10.1002","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-7173","authenticated-orcid":false,"given":"No\u00e9mi","family":"Dahan\u2010Oliel","sequence":"first","affiliation":[{"name":"Shriners Hospital for Children\u2010Canada  Montreal Quebec Canada"},{"name":"School of Physical and Occupational Therapy, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3343-4449","authenticated-orcid":false,"given":"Sarah","family":"Cachecho","sequence":"additional","affiliation":[{"name":"Shriners Hospital for Children\u2010Canada  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Barnes","sequence":"additional","affiliation":[{"name":"Shriners Hospital for Children\u2010Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5496-5084","authenticated-orcid":false,"given":"Tanya","family":"Bedard","sequence":"additional","affiliation":[{"name":"Clinical Genetics Alberta Congenital Anomalies Surveillance System, Alberta Health Services  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Davison","sequence":"additional","affiliation":[{"name":"Biology Department Kwantlen Polytechnic University  Surrey British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-4062","authenticated-orcid":false,"given":"Klaus","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Reference Center for Developmental Anomalies Centre Hospitalier Universitaire de Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Donohoe","sequence":"additional","affiliation":[{"name":"Nemours\/Alfred I duPont Hospital for Children  Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-846X","authenticated-orcid":false,"given":"Alicja","family":"F\u0105fara","sequence":"additional","affiliation":[{"name":"Faculty of Health Science, Jagiellonian University Medical College Institute of Physiotherapy, Arthrogryposis Treatment Centre, University Children's Hospital  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reggie","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Shriners Hospital for Children\u2010Canada  Montreal Quebec Canada"},{"name":"Division of Pediatric Orthopaedics McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helgi T.","family":"Hjartarson","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics Astrid Lindgren Children's Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naimisha","family":"S. 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