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These joint contractures are always secondary to diminished fetal movement which can have numerous causes that affect any part of the anatomical structures implicated in movement: the central nervous system, the anterior horn cell, the nerve, the neuromuscular junction, the muscle, or the joint itself. Make a precise diagnosis of the cause in a patient with multiple joint contractures is therefore challenging. The aim of this article is to summarize the use and diagnostic value of common examinations and analyses performed postnatally in patients affected by AMC from a literature review. We also compare this data with results from our clinical practice. Even though it is difficult to give precise guidelines today, it appears that genetic studies, such as whole exome or genome analysis in all patients and chromosomal microarray analysis in patients with intellectual disability and AMC should be preferred as first tier investigations over EMG and muscle biopsy.<\/jats:p>","DOI":"10.1002\/ajmg.c.31730","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T10:43:41Z","timestamp":1564656221000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The diagnostic workup in a patient with AMC: Overview of the clinical evaluation and paraclinical analyses with review of the literature"],"prefix":"10.1002","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-4062","authenticated-orcid":false,"given":"Klaus","family":"Dieterich","sequence":"first","affiliation":[{"name":"University of Grenoble Alpes, Inserm, U1216, GIN  Grenoble France"},{"name":"Department of Medical Genetics, CHU Grenoble Alpes G\u00e9n\u00e9tique M\u00e9dicale  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Le Tanno","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, CHU Grenoble Alpes G\u00e9n\u00e9tique M\u00e9dicale  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kimber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sahlgrenska Academy  Goteborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Simon","family":"Jouk","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, CHU Grenoble Alpes G\u00e9n\u00e9tique M\u00e9dicale  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Hall","sequence":"additional","affiliation":[{"name":"Children's &amp; Women's Health Centre of BC Medical Genetics, UBC  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-8064","authenticated-orcid":false,"given":"Philip","family":"Giampietro","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson School of Medicine Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961111)65:4<277::AID-AJMG6>3.0.CO;2-M"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84457"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"762","article-title":"Molecularetiology of arthrogryposis in multiple families of mostly Turkishorigin","volume":"126","author":"Bayram Y.","year":"2016","journal-title":"J ClinInvest."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1973"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118895"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.121148"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws344"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211185"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds514"},{"key":"e_1_2_7_11_1","volume-title":"Muscle disorders in childhood","author":"Dubowitz V.","year":"1995"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59565-2.00001-0"},{"key":"e_1_2_7_13_1","article-title":"Prenatal diagnosis in arthrogryposis multiplex congenita","author":"Filges I.","year":"2019","journal-title":"American Journal of Medical Genetics Part C: Seminars in Medical Genetics"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.02.079"},{"issue":"4","key":"e_1_2_7_15_1","first-page":"389","article-title":"Medina rams M. 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