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Partial loss\u2010of\u2010function variants in genes encoding the EZH2 and EED subunits of the complex lead to overgrowth, macrocephaly, advanced bone age, variable intellectual disability, and distinctive facial features.\n                    <jats:italic>EZH2<\/jats:italic>\n                    \u2010associated overgrowth, caused by constitutional heterozygous mutations within\n                    <jats:italic>Enhancer of Zeste homologue 2<\/jats:italic>\n                    (\n                    <jats:italic>EZH2<\/jats:italic>\n                    ), has a phenotypic spectrum ranging from tall stature without obvious intellectual disability or dysmorphic features to classical Weaver syndrome (OMIM #277590).\n                    <jats:italic>EED<\/jats:italic>\n                    \u2010associated overgrowth (Cohen\u2013Gibson syndrome; OMIM #617561) is caused by germline heterozygous mutations in\n                    <jats:italic>Embryonic Ectoderm Development<\/jats:italic>\n                    (\n                    <jats:italic>EED<\/jats:italic>\n                    ), and manifests overgrowth and intellectual disability (OGID), along with other features similar to Weaver syndrome. Most recently, rare coding variants in\n                    <jats:italic>SUZ12<\/jats:italic>\n                    have also been described that present with clinical characteristics similar to the previous two syndromes. Here we review the PRC2 complex and clinical syndromes of OGID associated with core components EZH2, EED, and SUZ12.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.c.31754","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T05:22:42Z","timestamp":1573708962000},"page":"519-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["PRC2\u2010complex related dysfunction in overgrowth syndromes: A review of\n                    <i>EZH2<\/i>\n                    ,\n                    <i>EED<\/i>\n                    , and\n                    <i>SUZ12<\/i>\n                    and their syndromic phenotypes"],"prefix":"10.1002","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-4163","authenticated-orcid":false,"given":"Sharri","family":"Cyrus","sequence":"first","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1743-7503","authenticated-orcid":false,"given":"Deepika","family":"Burkardt","sequence":"additional","affiliation":[{"name":"Center for Human Genetics, University Hospitals Rainbow Babies and Children\/Department of Genetics Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"},{"name":"British Columbia Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24570"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.558940"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.10.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/07434618.2015.1052152"},{"issue":"17","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1242\/dev.128.17.3371","article-title":"Su(z)12, a novel drosophila Polycomb group gene that is conserved in vertebrates and plants","volume":"128","author":"Birve A.","year":"2001","journal-title":"Development"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84894"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076997"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1742509"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203717666160122120008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.01.039"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20160173"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2016.51"},{"key":"e_1_2_8_15_1","volume-title":"GeneReviews\u00ae","author":"Cohen A. 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