{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:26:03Z","timestamp":1789403163783,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This introduction to the special issue of <jats:italic>AJMG Part C<\/jats:italic>: Overgrowth Syndromes updates the current understanding of overgrowth syndromes. We clarify the terminology associated with overgrowth, review some common pathways to overgrowth and present a preliminary classification based on currently known genomic and epigenetic mechanisms. We introduce the articles of this issue\u2014new research and reviews of well\u2010established and recently described overgrowth syndromes of the brain, body or both.<\/jats:p>","DOI":"10.1002\/ajmg.c.31757","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T02:04:39Z","timestamp":1575338679000},"page":"483-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Approach to overgrowth syndromes in the genome era"],"prefix":"10.1002","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1743-7503","authenticated-orcid":false,"given":"Deepika D.","family":"Burkardt","sequence":"first","affiliation":[{"name":"Center for Human Genetics University Hospitals  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8686-0973","authenticated-orcid":false,"given":"Katrina","family":"Tatton\u2010Brown","sequence":"additional","affiliation":[{"name":"South West Thames Regional Genetics Service, St George's University Hospitals NHS Foundation Trust  London UK"},{"name":"St George's University of London  London UK"},{"name":"Institute of Cancer Research  Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7681-2844","authenticated-orcid":false,"given":"William","family":"Dobyns","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neurology University of Washington School of Medicine, and Center for Integrative Brain Research, Seattle Children's Hospital  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John M.","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Cedars\u2010Sinai Medical Center  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"UpToDate","author":"Abramowicz J. 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