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In this study, we simulate how genetic screening may be implemented in the military to prevent an SCD endpoint resulting from hypertrophic cardiomyopathy (HCM). We created a logistic regression model to predict variant pathogenicity in the most common HCM associated genes <jats:italic>MYH7<\/jats:italic> and <jats:italic>MYBPC3.<\/jats:italic> Model predictions were used in conjunction with the gnomAD database to identify frequencies of pathogenic variants. Extrapolating these variants to a military population, lives saved and cost benefit analyses were conducted for screening for HCM related to pathogenic variants in <jats:italic>MYH7<\/jats:italic> and <jats:italic>MYBPC3.<\/jats:italic> Genetic screening for HCM followed by echocardiography in individuals with pathogenic variants is predicted to save an average of 2.9 lives per accession cohort, based on historical cohort sizes, and result in a break\u2010even cost of ~$7 per test. The false positives, defined as disqualified individuals for military service who do not have HCM, are predicted to be 0 individuals per accession cohort. This study suggests that the main barriers for the implementation of genetic screening for the U.S. military are the low detection rate and variant interpretation.<\/jats:p>","DOI":"10.1002\/ajmg.c.31772","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T04:59:32Z","timestamp":1581051572000},"page":"124-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic screening for hypertrophic cardiomyopathy in large, asymptomatic military cohorts"],"prefix":"10.1002","volume":"184","author":[{"given":"Joe","family":"Brough","sequence":"first","affiliation":[{"name":"Medical Genetics Branch National Human Genome Research Institute, National Institutes of Health  Bethesda Maryland"},{"name":"School of Medicine Stanford University  Palo Alto California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahim","family":"Jain","sequence":"additional","affiliation":[{"name":"Bone and Osteogenesis Imperfecta Department Kennedy Krieger Institute  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodoro","family":"Jerves","sequence":"additional","affiliation":[{"name":"Medical Genetics Branch National Human Genome Research Institute, National Institutes of Health  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4949-0875","authenticated-orcid":false,"given":"Paul","family":"Kruszka","sequence":"additional","affiliation":[{"name":"Medical Genetics Branch National Human Genome Research Institute, National Institutes of Health  Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"McGuffey","sequence":"additional","affiliation":[{"name":"Science and Mathematics Department U.S. Naval Academy  Annapolis Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.205"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.10.020"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr092"},{"key":"e_1_2_6_5_1","unstructured":"Cirino A. 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