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Established in 2003, BCFP is a voluntary and cooperative network aiming to investigate the health care of people with these diseases and other craniofacial anomalies. The initiatives and research results are presented in four sections: (a) a comprehensive report of the Brazilian public health system in craniofacial genetics; (b) multicentric studies developed on OFC and 22q11.2 DS; (c) education strategies focused on addressing these conditions for both population and health\u2010care professionals; and (d) the nosology through the Brazilian Database on Craniofacial Anomalies (BDCA). Since 2006, BDCA uses a standardized method with detailed clinical data collection, which allows for conducting studies on nosology, genotype\u2013phenotype correlations, and natural history; data can also contribute to public policies. Currently, the BDCA stores data on 1,724 individuals, including 1,351 (78.36%) who were primarily admitted due to OFC and 373 (21.63%) with clinical suspicion of 22q11.2 DS. Chromosomal abnormalities\/genomic imbalances were represented by 92\/213 (43.19%) individuals with syndromic OFC, including 43 with 22q11.2 DS, which indicates the need for chromosomal microarray analysis in this group. The nosologic diversity reinforces that monitoring clinical is the best strategy for etiological investigation. BCFP's methodology has introduced the possibility of increasing scientific knowledge and genetic diagnosis of OFC and 22q11.2 DS to in turn improve health care and policies for this group of diseases.<\/jats:p>","DOI":"10.1002\/ajmg.c.31852","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T19:14:13Z","timestamp":1604949253000},"page":"912-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Brazil's Craniofacial Project: Different approaches on orofacial clefts and 22q11.2 deletion syndrome"],"prefix":"10.1002","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-0554","authenticated-orcid":false,"given":"Vera L\u00facia","family":"Gil\u2010da\u2010Silva\u2010Lopes","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences, Department of Medical Genetics and Genomic Medicine University of Campinas (Unicamp)  Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0547-4913","authenticated-orcid":false,"given":"Milena Atique","family":"Tacla","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Department of Medical Genetics and Genomic Medicine University of Campinas (Unicamp)  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7253-7830","authenticated-orcid":false,"given":"Il\u00e1ria Cristina","family":"Sgardioli","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Department of Medical Genetics and Genomic Medicine University of Campinas (Unicamp)  Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-8341","authenticated-orcid":false,"given":"T\u00e1rsis Paiva","family":"Vieira","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Department of Medical Genetics and Genomic Medicine University of Campinas (Unicamp)  Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0992-2151","authenticated-orcid":false,"given":"Isabella Lopes","family":"Monlle\u00f3","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Clinical Genetics Service, University Hospital, Medical Genetics Sector Federal University of Alagoas\u2014UFAL  Macei\u00f3 Alagoas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-013-9570-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-11042017s12"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.2084"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1597\/05-177"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/247104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452753"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2017-105110"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000286"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2004.057760"},{"key":"e_1_2_8_11_1","unstructured":"Brazilian Iniciative of Precision Medicine (BIPMed). 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