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The first is X\u2010linked generalized hypertrichosis, an ultra\u2010rare disease, with few cases reported to date. The second is Cant\u00fa syndrome, also known as hypertrichotic osteochondrodysplasia, which has a wide spectrum of clinical manifestations and is caused by pathogenic variants in <jats:italic>ABCC9<\/jats:italic> and <jats:italic>KCNJ8<\/jats:italic>. The third is congenital hypertrichosis terminalis with or without gingival hyperplasia, which displays other features and involves several associated genes. The first two syndromes were described by the Mexican geneticist Jos\u00e9 Mar\u00eda Cant\u00fa, and the concept of atavistic genes was invoked to explain the emergence of this outstanding trait. By understanding the genetic and pathophysiological basis of hypertrichosis, we can offer effective treatment to patients and help solve esthetic problems related to hair growth.<\/jats:p>","DOI":"10.1002\/ajmg.c.31864","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T09:55:44Z","timestamp":1607334944000},"page":"1014-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Generalized hypertrichosis syndromes in Mexico"],"prefix":"10.1002","volume":"184","author":[{"given":"Thania Alejandra","family":"Aguayo\u2010Orozco","sequence":"first","affiliation":[{"name":"Divisi\u00f3n de Gen\u00e9tica, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente Instituto Mexicano del Seguro Social  Guadalajara Jalisco Mexico"},{"name":"Doctorado en Gen\u00e9tica Humana, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca Estela","family":"R\u00edos\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Familiar #92 Instituto Mexicano del Seguro Social  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Gabriela","family":"Castro\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Facultad de Medicina Universidad Aut\u00f3noma de Guadalajara  Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Virginia","family":"Ruiz\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Gen\u00e9tica, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente Instituto Mexicano del Seguro Social  Guadalajara Jalisco Mexico"},{"name":"Doctorado en Gen\u00e9tica Humana, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-4579","authenticated-orcid":false,"given":"Luis E.","family":"Figuera","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Gen\u00e9tica, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente Instituto Mexicano del Seguro Social  Guadalajara Jalisco Mexico"},{"name":"Doctorado en Gen\u00e9tica Humana, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara  Guadalajara Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-00938-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.72.5.457"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2012.08.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2008.09.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470213"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2013.09.009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00281261"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"141","article-title":"On atavisms and atavistic genes","volume":"28","author":"Cant\u00fa J. 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