{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:45:32Z","timestamp":1769877932364,"version":"3.49.0"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Virgin and Child<\/jats:italic>, a painting attributed to a follower of Andrea Mantegna completed around 1460, is currently in storage at the Museum of Fine Arts in Boston. With special supervised permission, I have visited the painting three times to assess whether this Christ child might have Down syndrome. My conclusion evolved each time\u2014as did my appreciation for the synergy between physicians and art historians.<\/jats:p>","DOI":"10.1002\/ajmg.c.31895","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T08:47:40Z","timestamp":1620895660000},"page":"213-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Can a Christ child have Down syndrome?"],"prefix":"10.1002","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-9882","authenticated-orcid":false,"given":"Brian G.","family":"Skotko","sequence":"first","affiliation":[{"name":"Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Virgin and child","author":"Follower of Andrea Mantegna"},{"key":"e_1_2_5_3_1","first-page":"2005","article-title":"Agonizing choice: A Brother's survey touches a nerve in abortion fight","volume":"3","author":"Marcus A. D.","year":"2005","journal-title":"Wall Street Journal"},{"key":"e_1_2_5_4_1","first-page":"2014","article-title":"Doctors enlist paintings to hone skills","volume":"31","author":"Marcus A. D.","year":"2014","journal-title":"Wall Street Journal"},{"key":"e_1_2_5_5_1","volume-title":"Common threads: Celebrating life with Down syndrome","author":"Skotko B. G.","year":"2001"},{"key":"e_1_2_5_6_1","first-page":"18","article-title":"On the antiquity of trisomy 21: Moving towards a quantitative diagnosis of down syndrome in historic material culture","volume":"2","author":"Starbuck J.","year":"2011","journal-title":"Journal of Contemporary Anthropology"},{"key":"e_1_2_5_7_1","first-page":"250","article-title":"Down's syndrome at the court of Mantua","volume":"7","author":"Stratford B.","year":"1982","journal-title":"Maternal and Child Health"}],"container-title":["American Journal of Medical Genetics Part C: Seminars in Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.c.31895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.c.31895","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.c.31895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:51:25Z","timestamp":1693007485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.c.31895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,13]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ajmg.c.31895"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.c.31895","archive":["Portico"],"relation":{},"ISSN":["1552-4868","1552-4876"],"issn-type":[{"value":"1552-4868","type":"print"},{"value":"1552-4876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,13]]},"assertion":[{"value":"2020-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}