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Herein, we hypothesized a higher proportion of respiratory and co\u2010occurring respiratory and GI medication prescription claims among persons with EDS compared to their matched controls with increases among peripubertal women with EDS. We compared the proportions of respiratory and co\u2010occurring respiratory and GI medication prescription claims among persons with EDS (aged 5\u201362) against their age\u2010, sex\u2010, state of residence\u2010, and earliest claim date\u2010matched controls using 10\u2009years of private prescription claims data. Prescription claims among persons with EDS versus matched controls were increased for eight medication classes (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001): intranasal\/inhaled corticosteroids (ICS) (30.8% vs. 19.0%), oral steroids (30.0% vs. 16.5%), H1\u2010antihistamines (26.2% vs. 12.2%), short\u2010acting beta agonists (22.7% vs. 11.6%), decongestants (21.6% vs. 15.9%), leukotriene modifiers (8.9% vs. 3.6%), ICS\/long\u2010acting beta agonists (5.7% vs. 2.9%), muscarinic antagonists (2.5% vs. 0.9%), and co\u2010occurring prescriptions (29% vs. 10%). Our results suggest a critical time window for peripubertal intervention and research and a need to focus on the pathogenesis and clinical evaluation of EDS\u2010specific respiratory and aerodigestive disorders.<\/jats:p>","DOI":"10.1002\/ajmg.c.31947","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T08:59:16Z","timestamp":1636707556000},"page":"549-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A <scp>case\u2013control<\/scp> study of respiratory medication and <scp>co\u2010occurring<\/scp> gastrointestinal prescription burden among persons with <scp>Ehlers\u2013Danlos<\/scp> syndromes"],"prefix":"10.1002","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-3476","authenticated-orcid":false,"given":"Rebecca","family":"Bascom","sequence":"first","affiliation":[{"name":"Department of Medicine Penn State Health Milton S. 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