{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:12:04Z","timestamp":1789103524214,"version":"build-2803163510"},"reference-count":122,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002014"],"award-info":[{"award-number":["UL1 TR002014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008321","name":"Pennsylvania State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Persons with the Ehlers\u2013Danlos syndromes (EDS) report a wide range of respiratory symptoms, most commonly shortness of breath, exercise limitation, and cough. Also reported are noisy breathing attributed to asthma, difficulty with deep inhalation, and inspiratory thoracic pain. The literature consists of case reports and small cross\u2010sectional and cohort studies. One case\u2013control study estimated twofold to threefold greater respiratory disease burden among persons with EDS as compared to controls. The differential diagnosis for symptoms is broad. Structural alterations include pectus deformities, scoliosis, recurrent rib subluxations, and tracheobronchomalacia, associated with varying degrees of physiologic impairment. Those with vascular EDS have an increased risk of pneumothorax, intrapulmonary bleeding, cysts, and nonmalignant fibrous nodules. Functional aerodigestive manifestations such as inducible laryngeal obstruction may be misdiagnosed as asthma, with gastro\u2010esophageal dysmotility and reflux as common contributing factors. Inflammatory manifestations include costochondritis, bronchiectasis, and localized respiratory allergic and nonallergic mast cell activation. Cranio\u2010cervical instability can dysregulate respiratory control pathways. There is a need for careful phenotyping using standardized clinical tools and patient\u2010reported outcomes and continuing collaboration with aerodigestive specialists including otolaryngologists and gastroenterologists. Also needed is further evaluation of respiratory symptoms in persons with hypermobility spectrum disorders. Personalized monitoring strategies are invaluable for interpretation and long\u2010term management of respiratory symptoms.<\/jats:p>","DOI":"10.1002\/ajmg.c.31953","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T07:37:32Z","timestamp":1637653052000},"page":"533-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Respiratory manifestations in the <scp>Ehlers\u2013Danlos<\/scp> syndromes"],"prefix":"10.1002","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-3476","authenticated-orcid":false,"given":"Rebecca","family":"Bascom","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Penn State College of Medicine Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-9136","authenticated-orcid":false,"given":"Radha","family":"Dhingra","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Public Health Sciences Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4032-7425","authenticated-orcid":false,"given":"Clair A.","family":"Francomano","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19627"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.166.4.518"},{"issue":"10","key":"e_1_2_10_4_1","first-page":"971","article-title":"Incidences h\u00e9morragiques et visc\u00e9rales de la maladie d'Ehlers\u2010Danlos [Visceral and hemorrhagic consequences of Ehlers\u2010Danlos disease]","volume":"116","author":"Andr\u00e9 R.","year":"1965","journal-title":"Bulletins et memoires de la Societe medicale des hopitaux de Paris"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08831-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(81)90011-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.40.4.300"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-39308-9.00017-0"},{"key":"e_1_2_10_9_1","author":"Bascom R.","year":"2021","journal-title":"American journal of medical genetics."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61054"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-53-630-598"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201709-1963IM"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-021-01501-0"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"Birchall M. Lam C.M.&Wood G.(2021). Throat and voice problems in Ehlers\u2010Danlos syndromes and hypermobility spectrum disorders.","DOI":"10.1002\/ajmg.c.31956"},{"key":"e_1_2_10_15_1","unstructured":"Part C Seminars in medical genetics 2021 The power of patient\u2010led global collaboration. American journal of medical genetics"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","unstructured":"American Journal of Medical Genetics Part C Seminars in Medical Genetics 2017 175 The international consortium on the Ehlers\u2010Danlos syndromes","DOI":"10.1002\/ajmg.c.31551"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1302901"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1212CI"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1_suppl.138S"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.31579\/2578-8868\/122"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.01.13"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4808"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.3.984"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.09.036"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/751768"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35483"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31539"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1976.tb04953.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0042-3"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/14799731211025313"},{"issue":"22","key":"e_1_2_10_31_1","first-page":"1847","article-title":"Le syndrome d'Ehlers\u2010Danlos. Une cause rare d'h\u00e9moptysie [Ehlers\u2010Danlos syndrome. A rare cause of hemoptysis]","volume":"10","author":"Cordier J. F.","year":"1981","journal-title":"La Nouvelle Presse Medicale"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2021.06.003"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0915-6"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201710-1981ST"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.07.012"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14077"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1996.tb02724.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203618"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.003"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-209560"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.07.132"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00004913"},{"key":"e_1_2_10_43_1","unstructured":"Global Initiative for Asthma. (2021).Global Strategy for Asthma Management and Prevention. National Heart Lung and Blood Institute National Institutes of Health. Retrieved from:www.ginasthma.org"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_2_10_45_1","first-page":"1777","article-title":"The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS)","volume":"27","author":"Grahame R.","year":"2000","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31543"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31954"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02221-2016"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588412X13171221499306"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.06.008"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2012.07.005"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.29390\/cjrt-2018-017"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31549"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.10.007"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150314"},{"issue":"20","key":"e_1_2_10_56_1","first-page":"356","article-title":"The diagnosis and treatment of acute cough in adults","volume":"111","author":"Holzinger F.","year":"2014","journal-title":"Deutsches Arzteblatt International"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.7.803"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050401"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1_suppl.80S"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.1818"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/1708538120925597"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-014-0504-9"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-35"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03574.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.09.038"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33498"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/23\/2\/318"},{"key":"e_1_2_10_68_1","unstructured":"Levin R. C. Mills S. E. Thompson E.A. Bascom R. &Schubart J.R.(2021).The impact of the COVID pandemic on dietary changes and gastric symptoms in people with Ehlers\u2010Danlos syndromes. Retrieved fromhttps:\/\/www.ehlers-danlos.com\/wp-content\/uploads\/PDF_dietary_changes_EDS_COVID_April-2021.pdf"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2008.03.004"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-005-0154-5"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-39308-9.00020-0"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.12.91"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2021200150"},{"issue":"7","key":"e_1_2_10_75_1","first-page":"721","article-title":"Dystrophie pulmonaire bulleuse au cours d'une maladie d'Ehlers\u2010Danlos. A propos d'une observation [vesicular pulmonary dystrophy during the course of Ehlers\u2010Danlos disease. With reference to one case (author's transl)]","volume":"19","author":"Mire B.","year":"1976","journal-title":"Annals of Radiology (Paris)"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072143"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062224"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.4947"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2011.02.029"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7506.1493"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.09.023"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00057.2019"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02938195"},{"key":"e_1_2_10_84_1","unstructured":"Online Mendelian Inheritance in Man. (2021). Retrieved fromOMIM.org\/entry\/225400"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.1704867"},{"key":"e_1_2_10_86_1","unstructured":"PCORI. (2021a).The STRETCH Project: To Build Capacity Advancing Patient\u2010centered Research in Ehlers\u2010Danlos Syndrome. Retrieved fromhttps:\/\/www.pcori.org\/research-results\/2018\/stretch-project-build-capacity-advancing-patient-centered-research-ehlers"},{"key":"e_1_2_10_87_1","unstructured":"PCORI. (2021b).Our Vision & Mission. Retrieved fromhttps:\/\/www.pcori.org\/about-us\/our-vision-mission"},{"key":"e_1_2_10_88_1","unstructured":"PCORI Methodology Standards(2021). Retrieved fromhttps:\/\/www.pcori.org\/research-results\/about-our-research\/research-methodology\/pcori-methodology-standards"},{"key":"e_1_2_10_89_1","unstructured":"PCORnet. (2021).The National Patient\u2010Centered Clinical Research Network. Retrieved fromhttps:\/\/pcornet.org\/data\/"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-015-0201-1"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153824"},{"issue":"12","key":"e_1_2_10_92_1","first-page":"e415","article-title":"Lung hypoplasia and patellar agenesis in Ehlers\u2010Danlos syndrome","volume":"50","author":"Pradhan P.","year":"2009","journal-title":"Singapore Medical Journal"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.204313"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.12.033"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61016"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-61-4-716"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2014.12.002"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3435"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066604269645"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0469MA"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0416TR"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61094"},{"key":"e_1_2_10_103_1","first-page":"A7663","article-title":"Respiratory symptoms among patients with Ehlers\u2010Danlos syndromes (EDS)","volume":"195","author":"Sheehan T. P.","year":"2017","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"5","key":"e_1_2_10_104_1","first-page":"239","article-title":"Pneumothorax in the Ehlers\u2010Danlos syndrome: Consequence of coincidence?","volume":"59","author":"Smit J.","year":"1978","journal-title":"Scandinavian Journal of Respiratory Disease"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1414215"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.06.002"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494328"},{"key":"e_1_2_10_108_1","unstructured":"The Ehlers\u2010Danlos Society. (2021).The EDS International Consortium identifies Common Data Elements as next collaborative goal. Retrieved fromhttps:\/\/www.ehlers-danlos.com\/2018-cdes\/"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2012.0009"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-016-9917-9"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2922-4"},{"key":"e_1_2_10_112_1","unstructured":"TruvenHealth. (2017).Marketscan databases and online tools. Retrieved fromhttp:\/\/truvenhealth.com\/your-healthcare-focus\/life-sciences\/data-databases-and-online-tools"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15647-5"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.40507"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy234"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0468-5"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21643"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-1164-4"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2260OE"},{"key":"e_1_2_10_120_1","volume-title":"Respiratory physiology: The essentials","author":"West J. B.","year":"2015"},{"issue":"2","key":"e_1_2_10_121_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/alr.22073","article-title":"International consensus statement on allergy and rhinology: Allergic rhinitis","volume":"8","author":"Wise S. K.","year":"2018","journal-title":"International Forum of Allergy & Rhinology"},{"key":"e_1_2_10_122_1","volume-title":"GeneReviews\u00ae","author":"Yeowell H. N.","year":"2000"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.5.1465"}],"container-title":["American Journal of Medical Genetics Part C: Seminars in Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.c.31953","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.c.31953","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.c.31953","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:59:15Z","timestamp":1693202355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.c.31953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,22]]},"references-count":122,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/ajmg.c.31953"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.c.31953","archive":["Portico"],"relation":{},"ISSN":["1552-4868","1552-4876"],"issn-type":[{"value":"1552-4868","type":"print"},{"value":"1552-4876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,22]]},"assertion":[{"value":"2021-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}