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Though having high sensitivity for SCID, NBS\u2010SCID has low specificity, therefore is able to detect other causes of lymphopenia in newborns including many inborn errors of immunity (IEIs). In a recent study, three of six newborns later diagnosed with Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome were found to have a low TRECs and lymphopenia at birth. This presents an opportunity to increase the detection and diagnosis of WHIM syndrome by NBS\u2010SCID with immunological follow\u2010up along with a combination of flow cytometry for immune cell subsets, absolute neutrophil count, and genetic testing, extending beyond the conventional bone marrow studies. Coupled with emerging technologies such as next\u2010generation sequencing, transcriptomics and proteomics, dried blood spots used in NBS\u2010SCID will promote earlier detection, diagnosis, and therefore treatment of IEIs such as WHIM syndrome.<\/jats:p>","DOI":"10.1002\/ajmg.c.32002","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T11:35:56Z","timestamp":1665401756000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Can we identify <scp>WHIM<\/scp> in infancy? 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