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We report two adult individuals\u2014a 60\u2010year\u2010old individual and a 24\u2010year\u2010old one, presenting with hearing loss, anterior eye segment dysgenesis, and very different severity of cerebral small vessel disease. Molecular testing documented the presence of <jats:italic>FOXC1<\/jats:italic> pathogenic variants in both individuals. Our paper documents the broad spectrum of radiological white matter involvement in adult individuals with <jats:italic>FOXC1<\/jats:italic>\u2010related disorders. Mild forms of <jats:italic>FOXC1<\/jats:italic>\u2010related small vessel disease, as we observed in individual 2, should be included in the list of genetic mimickers of MS.<\/jats:p>","DOI":"10.1002\/ajmg.c.32051","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T11:24:26Z","timestamp":1685532266000},"page":"167-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spectrum of white matter abnormalities associated with <scp><i>FOXC1<\/i><\/scp>\u2010related disorders in two unrelated cases"],"prefix":"10.1002","volume":"193","author":[{"given":"Tasnim","family":"Tabassum","sequence":"first","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9 Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Department of Neurology &amp; Neurosurgery Montreal Neurological Institute, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D'Agostino","family":"Maria Daniela","sequence":"additional","affiliation":[{"name":"Department of Human Genetics McGill University  Montreal Quebec Canada"},{"name":"Division of Medical Genetics, Department of Specialized Medicine McGill University Health Center  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-5065","authenticated-orcid":false,"given":"Roberta","family":"La Piana","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; 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