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This longitudinal study of 79 individuals (18\u201350\u2009years) with 22q11.2DS investigated neurodevelopmental (NDD) and psychiatric disorders in adulthood, evaluated the stability of childhood diagnoses over time, and examined associations between clinical characteristics in childhood\/adolescence and diagnostic outcome in adult age. Examination using validated instruments for cognitive, psychiatric, and global functional problems in the context of an in\u2010depth clinical evaluation found adult age stability of NDD diagnoses made in childhood, however, rates increased at follow\u2010up. Rates of anxiety, mood, and psychotic disorders were high, with a majority meeting diagnostic criteria for one or more psychiatric disorder. The rate of psychotic disorders was much lower compared to many other studies. Variability in functioning at follow\u2010up was primarily associated with intellectual ability at T1. The findings obtained highlight the increased risk of NDD and psychiatric problems and of cognitive impairment and reduced levels of global functioning over time. Results emphasize the importance of clinical follow\u2010up to enable appropriate support for the promotion of optimal health along with a need for future research on effective interventions and treatment strategies.<\/jats:p>","DOI":"10.1002\/ajmg.c.32052","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T01:19:14Z","timestamp":1685409554000},"page":"172-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neurodevelopmental and other psychiatric disorders in 22q11.2 deletion syndrome from childhood to adult age: Prospective longitudinal study of 100 individuals"],"prefix":"10.1002","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2519-8811","authenticated-orcid":false,"given":"Lena","family":"Wallin","sequence":"first","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Psychiatry, Cognition and Old Age Psychiatry Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Gillberg","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Fernell","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Gillberg","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Billstedt","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Child Neuropsychiatry Clinic Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","unstructured":"Achenbach T. 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