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In biallelic phenotypes, such overlaying mosaic involvement may coexist with disseminated mosaicism, for example, in neurofibromatosis or tuberous sclerosis. In other phenotypes, however, classical nonsegmental involvement tends to appear much later, which is why the superimposed mosaic is a heralding feature. In Brooke\u2013Spiegler syndrome (eccrine cylindromatosis), a large pedigree documented a 5\u2010year\u2010old boy with multiple, congenital small eccrine cylindromas along the lines of Blaschko. Disseminated cylindromas were absent because they usually appear in adulthood. \u0336 In Hornstein\u2013Knickenberg syndrome, an affected woman had an 8\u2010year\u2010old son with a nevus comedonicus\u2010like lesion exemplifying a forerunner of the syndrome. (\u201cBirt\u2010Hogg\u2010Dub\u00e9 syndrome\u201d represents a nonsyndromic type of hereditary perifollicular fibromas.) In glomangiomatosis, neonatal superimposed mosaicism is a heralding feature because disseminated lesions appear during puberty or adulthood. Linear porokeratosis is a harbinger of disseminated porokeratosis that develops 30 or 40\u2009years later. \u0336 Cases of superimposed linear Darier disease were forerunners of nonsegmental manifestation. \u0336 In a case of Hailey\u2013Hailey disease, neonatal mosaic lesions heralded nonsegmental involvement that began 22\u2009years later.<\/jats:p>","DOI":"10.1002\/ajmg.c.32055","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T10:50:35Z","timestamp":1686221435000},"page":"109-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autosomal dominant genodermatoses in adults being heralded by superimposed skin lesions in children"],"prefix":"10.1002","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-1766","authenticated-orcid":false,"given":"Rudolf","family":"Happle","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical Center\u2014University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.0215"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.12.017"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.0016"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1977.01640120042005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/339492"},{"key":"e_1_2_12_7_1","first-page":"242","article-title":"Fibromes sous\u2010cutan\u00e9s p\u00e9ripilaires multples du cou","volume":"32","author":"Burnier R.","year":"1925","journal-title":"Bulletin de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie et de Syphiligraphie."},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60660-2"},{"key":"e_1_2_12_9_1","first-page":"100","article-title":"Fibromes p\u00e9rifolliculaires multiples du visage et du cou","volume":"78","author":"Civatte J.","year":"1971","journal-title":"Bulletin de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie et de Syphiligraphie"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1987.tb00780.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660200059015"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00497795"},{"issue":"1219","key":"e_1_2_12_13_1","article-title":"Scaly atrophic lesions both scattered and in linear arrays. 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