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A wide range of ocular complications are seen in children with Down syndrome, including strabismus, nystagmus, refractive errors, congenital cataracts, the presence of keratoconus, and decreased visual acuity. Early ophthalmic examination is needed for early diagnosis and treatment in patients. This narrative review examines ocular manifestations in children with Down syndrome and the importance of prompt ophthalmic interventions for treatment.<\/jats:p>","DOI":"10.1002\/ajmg.c.32068","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:20:04Z","timestamp":1696519204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ophthalmologic and neuro\u2010ophthalmologic findings in children with Down syndrome"],"prefix":"10.1002","volume":"193","author":[{"given":"Aarushi","family":"Jain","sequence":"first","affiliation":[{"name":"Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie K.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli C.","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin N.","family":"Vogel","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Santoro","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Department of Neurology Keck School of Medicine at the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20090301-04"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5301"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.41"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816819609057864"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2010.488562"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2014.05.002"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-14-59"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1981.tb02047.x"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992288902800804"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2010.01334.x"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2012.09.011"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(90)90116-D"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00410-X"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20090301-06"},{"issue":"1","key":"e_1_2_19_16_1","first-page":"55","article-title":"Accommodation and refractive error in children with Down syndrome: Cross\u2010sectional and longitudinal studies","volume":"42","author":"Cregg M.","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72015-X"},{"key":"e_1_2_19_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85037-4"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.150424"},{"key":"e_1_2_19_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210701700521"},{"key":"e_1_2_19_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12605"},{"key":"e_1_2_19_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4626-6"},{"key":"e_1_2_19_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.090639"},{"key":"e_1_2_19_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.18.120184.000441"},{"key":"e_1_2_19_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790613.x"},{"key":"e_1_2_19_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0951"},{"key":"e_1_2_19_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961016)65:2<160::AID-AJMG16>3.0.CO;2-O"},{"key":"e_1_2_19_28_1","volume-title":"StatPearls","author":"Kanukollu V. 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