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Eligible participants were recruited from a specialty clinic for persons with DS at a large medical center. Age and gender\u2010matched participants also with DS but without skill loss were used as a comparison group. Case and control participants were between 3 and 14\u2009years (mean 7.6\u2009yr) at the time of evaluation. Loss of previously acquired communication, social\u2010communication, and play skills was experienced by all cases, as well as new\u2010onset or intensification of pre\u2010existing maladaptive behaviors. The Aberrant Behavior Checklist (ABC)\u2010community was helpful in distinguishing group differences in maladaptive behavior among cases and controls. All cases met DSMIV criteria for autism. Developmental skill loss associated with autism is an extreme example of within\u2010group phenotypic variability and needs to be the focus of further research.<\/jats:p>","DOI":"10.1002\/ajmg.c.32077","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T08:36:40Z","timestamp":1700210200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Children with Down syndrome who experience developmental skill loss, characterization, and phenomenology: A case series"],"prefix":"10.1002","volume":"193","author":[{"given":"Susana","family":"Bernad\u2010Ripoll","sequence":"first","affiliation":[{"name":"Department of Human and Social Sciences Universidad Pontifica de Comillas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Division of Developmental &amp; Behavioral Pediatrics, Child Neurology Ann &amp; Robert Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-3730","authenticated-orcid":false,"given":"George T.","family":"Capone","sequence":"additional","affiliation":[{"name":"Neurodevelopmental Medicine Kennedy Krieger Institute  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S32767"},{"key":"e_1_2_12_3_1","volume-title":"Diagnostic and statistical manual of mental disorders IV\u2010TR","author":"APA","year":"2000"},{"key":"e_1_2_12_4_1","volume-title":"Diagnostic and statistical manual of mental disorders V","author":"APA","year":"2013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-006-0201-3"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12376"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36052"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30622"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30097"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073816634854"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14127"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4105.1125"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e318165c78d"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386495-6.00007-2"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3181d5aa6d"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20159"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.2002.00431.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(03)00088-3"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811405201"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.01.009"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00239-X"},{"key":"e_1_2_12_22_1","first-page":"1171","article-title":"Retrospective studies and chart reviews","volume":"49","author":"Hess D.","year":"2004","journal-title":"Respiratory Care"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1999.tb00574.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.644324"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283319a9a"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001691"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199110000-00004"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11101278"},{"key":"e_1_2_12_29_1","unstructured":"O'Neill M. 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