{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:49:18Z","timestamp":1790336958897,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt C"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The National Institutes of Health (NIH) has a long\u2010standing history of support for research in Down syndrome (DS). In response to a 2018 congressional directive for a trans\u2010NIH initiative to address medical issues in DS, NIH launched the INCLUDE Project (INvestigation of Co\u2010occurring conditions across the Lifespan to Understand Down syndromE). Reflecting the three INCLUDE components of basic science research, cohort development, and clinical trials, the Project has published funding opportunities to address conditions such as immune disorders and Alzheimer's disease. Due to a steady expansion in dedicated funding over its first 5\u2009years, INCLUDE has invested $258 M in over 250 new research projects. INCLUDE also supports training initiatives to expand the number and diversity of investigators studying DS. NIH has funded an INCLUDE Data Coordinating Center that is collecting de\u2010identified clinical information and multi\u2010omics data from research participants for broad data sharing and secondary analyses. Through the DS\u2010Connect\u00ae registry, INCLUDE investigators can access recruitment support. The INCLUDE Research Plan articulates research goals for the program, with an emphasis on diversity of research participants and investigators. Finally, a new Cohort Development Program is poised to increase the impact of the INCLUDE Project by recruiting a large DS cohort across the lifespan.<\/jats:p>","DOI":"10.1002\/ajmg.c.32081","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T07:08:38Z","timestamp":1704870518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The National Institutes of Health\n                    <scp>INvestigation<\/scp>\n                    of\n                    <scp>C<\/scp>\n                    o\u2010occurring conditions across the\n                    <scp>L<\/scp>\n                    ifespan to\n                    <scp>U<\/scp>\n                    nderstand\n                    <scp>D<\/scp>\n                    own\n                    <scp>syndromE<\/scp>\n                    (\n                    <scp>INCLUDE<\/scp>\n                    ) Project: Accelerating research discoveries for people with Down syndrome across the lifespan"],"prefix":"10.1002","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9460-0354","authenticated-orcid":false,"given":"Sujata","family":"Bardhan","sequence":"first","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Li","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Tarver","sequence":"additional","affiliation":[{"name":"National Institute on Aging (NIA), NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Schramm","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marishka","family":"Brown","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Garcia","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryanna","family":"Schwartz","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mazzucco","sequence":"additional","affiliation":[{"name":"Office of the Director, NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikila","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Office of the Director, NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1353-2564","authenticated-orcid":false,"given":"Elizabeth","family":"Walsh","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Ryan","sequence":"additional","affiliation":[{"name":"National Institute on Aging (NIA), NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Pearson","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-1004","authenticated-orcid":false,"given":"Melissa A.","family":"Parisi","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0143-7"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-022-09435-z"},{"key":"e_1_2_16_4_1","unstructured":"Centers for Disease Control and Prevention. 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