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A comprehensive literature search was conducted in the medical databases PubMed, Embase, and CINAHL. The selection of studies was guided by specific eligibility criteria. Extracted data was arranged in a review matrix, and study quality was assessed using a methodological quality score (MQS). Twenty\u2010seven studies were selected for review, including 21 retrospective studies, five case reports, and one prospective study. The mean MQS across studies was 9.7 points (low to moderate). Across the included studies, nine categories of factors were investigated in association with parental decisions, including five pregnancy\u2010related categories (ultrasound\u2010detected abnormalities, karyotype, gestational age at diagnosis, time period of diagnosis, and prenatal counseling) and four categories related to expectant parents (age, reproductive history, expectations\/concerns about the child's prognosis, and socio\u2010demographic characteristics). Among these, ultrasound\u2010detected abnormalities, karyotype, and counseling emerged as key factors influencing parental decisions. Parental decisions following a PND of TS are influenced by a complex interplay of medical, psychological, and socio\u2010cultural factors. Addressing these determinants through patient\u2010centered, non\u2010directive counseling and equitable access to genetic expertise can support informed decision making.<\/jats:p>","DOI":"10.1002\/ajmg.c.32140","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T07:25:12Z","timestamp":1744097112000},"page":"72-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Parental Decision\u2010Making Following a Prenatal Diagnosis of Turner Syndrome: A Systematic Review"],"prefix":"10.1002","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-9233","authenticated-orcid":false,"given":"Inger Lily Hjuler","family":"Dorf","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Genetics Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Molecular Medicine Aarhus University 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