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This multisite cross\u2010sectional study described developmental status and examined factors associated with milestone attainment in 143 children aged 0\u201366\u2009months from a pediatric AMC Registry. Development was assessed using the Ages and Stages Questionnaire, Third Edition (ASQ\u20103), across Communication, Gross Motor, Fine Motor, Problem\u2010Solving, and Personal\u2013Social domains. Independent variables included demographic, perinatal, clinical, and parental factors. Gross Motor function was the most limited domain, with more than 90% scoring close to\/below the ASQ\u20103 domain\u2010specific cutoff (\u2265\u20092 SD below normative mean). Personal\u2013Social scores were unexpectedly low, and Fine Motor limitations were also frequent, with 53.1% scoring close to\/below the cutoff. Communication and Problem\u2010Solving were relative strengths. Longer neonatal intensive\u2010care unit stays were linked to poorer Communication and Fine Motor scores, and higher birth weight was associated with better Problem\u2010Solving performance. Specific joint contractures, particularly those affecting the neck, shoulder, elbow, and knee, were associated with lower performance across domains, while higher parental education was related to better Personal\u2013Social outcomes. Developmental attainment in AMC is shaped by interactions among musculoskeletal, perinatal, and family factors, underscoring the importance of early, coordinated orthopedic, developmental and family\u2010centered interventions.<\/jats:p>","DOI":"10.1002\/ajmg.c.70006","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T08:35:40Z","timestamp":1773650140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Milestone Attainment in Young Children With Arthrogryposis Multiplex Congenita: Developmental Profile\u00a0and Associated Factors"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-0009","authenticated-orcid":false,"given":"Ahlam","family":"Zidan","sequence":"first","affiliation":[{"name":"School of Physical and Occupational Therapy McGill University  Montreal Quebec Canada"},{"name":"Department of Clinical Research Shriners Hospitals for Children  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