{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:46:46Z","timestamp":1785836806504,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cases with congenital heart defects (CHD) often have other associated anomalies. The aim of this investigation was to assess the prevalence and the types of co\u2010occurring anomalies in CHD in a well\u2010defined population. The anomalies co\u2010occurring with CHD were ascertained in all live births, stillbirths and terminations of pregnancy for fetal anomaly during 29\u2009years in 387,067 consecutive pregnancies of known outcome in the area covered by our population\u2010based registry of congenital anomalies. Of the 4640 cases with CHD ascertained during this period (prevalence of 119.9 per 10,000), 1228 (26.5%) had associated major anomalies. There were 410 (8.8%) cases with chromosomal abnormalities including 253 trisomies 21 (62%), and 114 (2.5%) syndromes including 23 cases with VACTERL association (24%). Seven hundred and four (15.2%) of the cases had non\u2010syndromic, non\u2010chromosomal multiple congenital anomalies (MCA). Anomalies in the urogenital, musculoskeletal, gastrointestinal, ear, face, and neck, and central nervous systems were the most common other anomalies. In conclusion the overall prevalence of co\u2010occurring anomalies which was one in four cases emphasizes the need for a thorough investigation of cases with CHD. Routine screening for other anomalies may be considered in cases with CHD. One should be aware that the anomalies associated with CHD can be classified into a recognizable anomaly, chromosomal or syndromic in one out of 10 cases with CHD.<\/jats:p>","DOI":"10.1002\/ajmga.70002","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:55:36Z","timestamp":1775710536000},"page":"1953-1972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Co\u2010Occurring Non\u2010Cardiac Congenital Anomalies Among Cases With Congenital Heart Defects"],"prefix":"10.1002","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-9257","authenticated-orcid":false,"given":"Claude","family":"Stoll","sequence":"first","affiliation":[{"name":"Laboratoire de Genetique Medicale, Faculte de Medecine  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Alembik","sequence":"additional","affiliation":[{"name":"Laboratoire de Genetique Medicale, Faculte de Medecine  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule","family":"Roth","sequence":"additional","affiliation":[{"name":"Laboratoire de Genetique Medicale, Faculte de Medecine  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-023-03308-5"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"695","article-title":"Spectrum of Associated Congenital Heart Defects in Patients With \u201cNon\u2010Cardiac Congenital Defects at a Tertiary Care Children Hospital in Pakistan","volume":"37","author":"Arshad M. 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