{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:18:58Z","timestamp":1792113538533,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH\u201019\u20101\u20100618"],"award-info":[{"award-number":["W81XWH\u201019\u20101\u20100618"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neurofibromatosis Type 1 (NF1) is an autosomal dominant genetic disorder that presents with severe chronic pain (CP) in adults. A limited number of NF1 research studies have evaluated behaviorally based interventions to address CP. The current study evaluated the efficacy of cognitive behavior therapy delivered via mobile application. The three\u2010arm (treatment as usual [control], iCanCope only [iCC\u2010NF], iCanCope\u2009+\u2009contingency management [iCC\u2010NF\u2009+\u2009CM]) randomized clinical trial of 108 adults with NF1 and CP was completed during a 2\u2010month intervention period. Significant improvements in pain interference (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.815) occurred in the iCC\u2010NF\u2009+\u2009CM group when compared to the control group. Outcomes for pain self\u2010efficacy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.718), pain inflexibility (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.629), and chronic pain acceptance (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036,\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.653) significantly improved among the iCC\u2010NF\u2009+\u2009CM group when compared to the control group. No significant differences were noted between iCC\u2010NF\u2009+\u2009CM and iCC\u2010NF. The current findings offer preliminary evidence of the added benefit of contingency management to mobile pain applications and provide an auxiliary treatment option for individuals with NF1.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: 2000029045.\n                  <\/jats:p>","DOI":"10.1002\/ajmga.70004","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T07:27:17Z","timestamp":1764919637000},"page":"814-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Efficacy of the\n                    <scp>iCanCope<\/scp>\n                    Mobile Application for Neurofibromatosis Type 1 (\n                    <scp>NF1<\/scp>\n                    ): A Three\u2010Arm Randomized\u00a0Controlled Trial"],"prefix":"10.1002","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-7857","authenticated-orcid":false,"given":"Frank D.","family":"Buono","sequence":"first","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Blaha","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Lalloo","sequence":"additional","affiliation":[{"name":"Institute for Health Policy, Management, and Evaluation, University of Toronto  Toronto Ontario Canada"},{"name":"The Research Institute, The Hospital of Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Larkin","sequence":"additional","affiliation":[{"name":"Northern Illinois University  DeKalb Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Zempsky","sequence":"additional","affiliation":[{"name":"Connecticut Children's  Hartford Connecticut USA"},{"name":"School of Medicine University of Connecticut  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh","family":"Pham","sequence":"additional","affiliation":[{"name":"Centre for Digital Therapeutics University Health Network  Toronto Ontario Canada"},{"name":"Lawrence Bloomberg Faculty of Nursing University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauretta E.","family":"Grau","sequence":"additional","affiliation":[{"name":"Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer N.","family":"Stinson","sequence":"additional","affiliation":[{"name":"Institute for Health Policy, Management, and Evaluation, University of Toronto  Toronto Ontario Canada"},{"name":"The Research Institute, The Hospital of Sick Children  Toronto Ontario Canada"},{"name":"Lawrence Bloomberg Faculty of Nursing University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12695"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2196\/35120"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/b978\u20100\u2010444\u201062702\u20105.00004\u20104"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.08.035"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010030711"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010015\u20100641\u2010z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001486"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2196\/12028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.08.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S209540"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2021.100883"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15123213"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.63541"},{"key":"e_1_2_10_15_1","volume-title":"National Conference in Pediatric Psychology, San Antonio, TX","author":"Burns K. 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