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Next\u2010Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes. Most clinical sequencing providers streamline their wet\u2010bench workflows by sequencing the entire exome or genome, followed by targeted bioinformatic extraction of variant data from a pre\u2010specified gene set. Thus, additional data on these patients remain available but are only reviewed by special request. We interrogated clinical\u2010grade sequencing data on two out of three affected members of a family with childhood\u2010onset adrenal insufficiency in whom an autosomal recessive condition was suspected. Review of clinome data identified heterozygosity for\n                    <jats:italic>CYP11A1<\/jats:italic>\n                    variants c.644T&gt;C; p.(Phe215Ser) and c.1187G&gt;A; p.(Arg396Lys) in both affected sibs. Long\u2010read whole genome sequencing of the proband showed these variants were in\n                    <jats:italic>trans<\/jats:italic>\n                    , confirming compound heterozygosity and resolving the molecular etiology of the clinical diagnosis.\n                  <\/jats:p>","DOI":"10.1002\/ajmga.70008","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T01:30:01Z","timestamp":1765589401000},"page":"923-928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Compound Heterozygous\n                    <i>CYP11A1<\/i>\n                    Variants via Reanalysis of Clinical Sequencing Data"],"prefix":"10.1002","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4989-4440","authenticated-orcid":false,"given":"Ana","family":"Acosta Bed\u00f3n","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8005-7776","authenticated-orcid":false,"given":"Vahid","family":"Akbari","sequence":"additional","affiliation":[{"name":"Canada's Michael Smith Genome Sciences Centre, BC Cancer  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4658-7121","authenticated-orcid":false,"given":"Ralph","family":"Rothstein","sequence":"additional","affiliation":[{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Division of Endocrinology &amp; Diabetes, Department of Pediatrics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Inman","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Radiology Surrey Memorial Hospital  Surrey British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6299-1327","authenticated-orcid":false,"given":"Jianghong","family":"An","sequence":"additional","affiliation":[{"name":"Canada's Michael Smith Genome Sciences Centre, BC Cancer  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7482-9570","authenticated-orcid":false,"given":"Jan M.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-4150","authenticated-orcid":false,"given":"Rosanna","family":"Weksberg","sequence":"additional","affiliation":[{"name":"Program in Genetics and Genome Biology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Molecular Genetics University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-241X","authenticated-orcid":false,"given":"Cornelius","family":"Boerkoel","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Provincial Medical Genetics Program BC Women's Hospital  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-2208","authenticated-orcid":false,"given":"Steven J. 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