{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:02:39Z","timestamp":1779782559915,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The pediatric Down syndrome (DS) clinic model improves medical care access and treatment; however, evidence\u2010based outcomes of this model implementing routine screening are not well documented. Our goal was to evaluate the impact of the pediatric DS clinic on the identification of children with DS and celiac disease using a large patient population. This is a retrospective review of a large cohort of children with DS ages 3\u201322\u2009years (total\u2009=\u20094158; 2011\u20132024 Sie Center for DS [SCDS] patients\u2009=\u20092164; 2011\u20132024 Children's Hospital Colorado [CHCO] patients with DS not seen at SCDS\u2009=\u2009924; 1998\u20132010 CHCO patients with DS receiving care at CHCO before the SCDS\u2009=\u20091070) at a large pediatric hospital. Symptoms present, type and frequency of testing completed, and other co\u2010occurring conditions were reviewed. The pediatric DS clinic model using routine screening significantly increased the identification of celiac disease (7.4%,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009160\/2164 vs. 2.4% and 2.8%) with the majority identified by routine screening rather than current American Academy of Pediatrics (AAP) DS Guidelines' recommendations. Impact of repeat screenings and co\u2010occurring condition risk ratios is reported. The pediatric DS clinic model implementing routine screening improves patient identification for celiac disease. Our results should be considered when updating celiac disease testing recommendations in the AAP DS Guidelines for this unique population.\n                  <\/jats:p>","DOI":"10.1002\/ajmga.70064","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:15:21Z","timestamp":1768979721000},"page":"1215-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of a Pediatric Down Syndrome Clinic on the Identification of Celiac Disease in the Patient Population"],"prefix":"10.1002","volume":"200","author":[{"given":"Francis","family":"Hickey","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Colorado, School of Medicine  Aurora USA"},{"name":"Anna and John J. Sie Center for Down Syndrome Children's Hospital Colorado  Aurora USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-1323","authenticated-orcid":false,"given":"Kristine","family":"Wolter\u2010Warmerdam","sequence":"additional","affiliation":[{"name":"Anna and John J. Sie Center for Down Syndrome Children's Hospital Colorado  Aurora USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz","family":"Maastricht","sequence":"additional","affiliation":[{"name":"Anna and John J. Sie Center for Down Syndrome Children's Hospital Colorado  Aurora USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dee","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado, School of Medicine  Aurora USA"},{"name":"Anna and John J. Sie Center for Down Syndrome Children's Hospital Colorado  Aurora USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kelminson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado, School of Medicine  Aurora USA"},{"name":"Anna and John J. Sie Center for Down Syndrome Children's Hospital Colorado  Aurora USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/637187"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-057010"},{"key":"e_1_2_10_4_1","article-title":"1268 A Retrospective Study of Coeliac Disease Screening Among Children and Young People With Down's Syndrome","volume":"106","author":"Church J.","year":"2021","journal-title":"BMJ Journals"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jppi.12471"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001216"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002742"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13668250.2011.570253"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.12.087"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922820941247"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20735"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v5.i7.264"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.53350\/pjmhs2115102582"},{"key":"e_1_2_10_15_1","first-page":"2041","article-title":"Celiac Disease in Patients With Down","volume":"11","author":"Safi M. A. A.","year":"2019","journal-title":"International Journal of Current Research"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v10.i4.53"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922816652416"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i32.4493"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35795"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17024"},{"issue":"6","key":"e_1_2_10_21_1","first-page":"589","article-title":"Enfermedad cel\u00edaca en ni\u00f1os con s\u00edndrome de Down","volume":"90","author":"Velasco\u2010Ben\u00edtez C. A.","year":"2019","journal-title":"Revista Chilena de Pediatr\u00eda"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmga.70064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmga.70064","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmga.70064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:10:05Z","timestamp":1779779405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmga.70064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ajmga.70064"],"URL":"https:\/\/doi.org\/10.1002\/ajmga.70064","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"2025-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}