{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:04:25Z","timestamp":1784153065820,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2022\u201000510_VR"],"award-info":[{"award-number":["2022\u201000510_VR"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In epidemiological studies, obsessive\u2010compulsive disorder (OCD) is robustly associated with increased risk of cardiometabolic disorders, including cardiovascular diseases, type 2 diabetes, and obesity. However, the mechanisms behind these associations are unclear. We conducted genetic correlation analyses to explore shared genetic etiology and bi\u2010directional summary\u2010level Mendelian randomization (MR) to explore potential causal effects between genetic liability to OCD and 14 cardiometabolic phenotypes (e.g., coronary artery disease, blood pressure, body mass index [BMI]). If causal effects were observed, we planned to conduct multivariable MR to explore indirect effects via health behaviors. We found no evidence for genetic correlations between OCD and any of the cardiometabolic phenotypes under study, except for a negative correlation with BMI (rG\u2009=\u2009\u22120.123, SE\u2009=\u20090.029,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Summary\u2010level MR showed no evidence for causal effects. Therefore, multivariable MR was not conducted. We found limited evidence for shared genetic etiology or causal effects using the largest OCD GWAS to date. However, we were predominantly only powered to detect medium to large effects in the direction of OCD to cardiometabolic traits, leaving the possibility of smaller causal effects existing. Future studies with larger, more representative samples will help to further interpret findings.\n                  <\/jats:p>","DOI":"10.1002\/ajmgb.70003","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T06:59:17Z","timestamp":1768373957000},"page":"321-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Are There Causal Associations Between Obsessive\u2010Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic Correlation and Bi\u2010Directional Mendelian Randomization Study"],"prefix":"10.1002","volume":"201","author":[{"given":"Robyn E.","family":"Wootton","sequence":"first","affiliation":[{"name":"School of Psychological Science University of Bristol  Bristol UK"},{"name":"Medical Research Council (MRC) Integrative Epidemiology Unit, Bristol Medical School University of Bristol  Bristol UK"},{"name":"Psychiatric Genetic Epidemiology Group, Research Department Lovisenberg Diaconal Hospital  Oslo Norway"},{"name":"PsychGen Centre for Genetic Epidemiology and Mental Health Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-1557","authenticated-orcid":false,"given":"James J.","family":"Crowley","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm  Stockholm Sweden"},{"name":"Department of Genetics University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-3649","authenticated-orcid":false,"given":"Josep","family":"Pol\u2010Fuster","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet &amp; Stockholm Health Care Services, Region Stockholm  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"R\u00fcck","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, 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