{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:26:29Z","timestamp":1784831189157,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,5,16]],"date-time":"2001-05-16T00:00:00Z","timestamp":989971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Primatol"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>New World primates (NWPs) have high circulating 1,25\u2010dihydroxyvitamin D (1,25\u2010(OH)<jats:sub>2<\/jats:sub>D) levels. Comparable levels would be harmful to Old World primates (OWPs) and humans. Thus, NWPs must have developed mechanisms of 1,25\u2010(OH)<jats:sub>2<\/jats:sub>D resistance to survive. In humans, patients with hypocalcemic vitamin D\u2010resistant rickets type II have high circulating vitamin D levels and vitamin D resistance due to expression of a dysfunctional vitamin D receptor (VDR). To examine if this could wholly or in part explain vitamin D resistance in NWPs, VDR from <jats:italic>Saguinus oedipus<\/jats:italic> (cotton top tamarin) NWP B95\u20108 cells was cloned by reverse\u2010transcription polymerase chain reaction (RT\u2010PCR). The NWP VDR cDNA sequence showed 96% homology at the DNA level and 98% homology at the amino acid level compared to human VDR. To assay for function, NWP VDR cDNA was transiently transfected into CV\u20101 cells with a vitamin D response element reporter plasmid. No difference between OWP and NWP VDR\u2010directed transactivation was observed. These results indicate that the mechanism of vitamin D resistance in NWPs is not due to a dysfunctional VDR, and is consistent with our hypothesis that vitamin D resistance in NWPs is mediated by overexpression of a VDR\u2010independent vitamin D response element binding protein. Am. J. Primatol. 54:107\u2013118, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajp.1016","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:11:41Z","timestamp":1030313501000},"page":"107-118","source":"Crossref","is-referenced-by-count":23,"title":["Cloning, sequencing, and functional characterization of the vitamin D receptor in vitamin D\u2010resistant New World primates"],"prefix":"10.1002","volume":"54","author":[{"given":"Rene F.","family":"Chun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorrie","family":"Boldrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Sweet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,5,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.41.23906"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.10.3294"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.9.5774"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119210"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.47.31352"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007117200"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-3-516"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-115-1-25"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-5-12-1815"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115108"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.6.2581"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.1350280404"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080105"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.13.8433"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.4.1264"},{"key":"e_1_2_1_17_1","first-page":"S57","article-title":"The vitamin D hormone and its nuclear receptor: molecular actions and disease states","author":"Haussler MR","year":"1997","journal-title":"J Endocrinol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.3.325"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb02424.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19980701)70:1<94::AID-JCB10>3.0.CO;2-B"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9916574"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)00735-B"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1210\/endo.138.6.5210","article-title":"Cloning and characterization of the vitamin D receptor from Xenopus laevis","volume":"138","author":"Li YC","year":"1997","journal-title":"Endocrinology"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9751"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.9864"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb19004.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"18808","DOI":"10.1016\/S0021-9258(18)55135-8","article-title":"Baculovirus\u2010mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions, and evidence for a receptor auxiliary factor","volume":"266","author":"MacDonald PN","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.9.5907"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.20.2.156"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3029866"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.47.33531"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.6.1398"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.1.190"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80655-8"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.27.19352"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.14.3.0411"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.256"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5101-6_28"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2378"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1210\/mend.14.9.0523","article-title":"Intracellular vitamin D binding proteins: novel facilitators of vitamin D\u2010directed transactivation","volume":"14","author":"Wu S","year":"2000","journal-title":"Mol Endocrinol"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555736"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.30.19027"}],"container-title":["American Journal of Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajp.1016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajp.1016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T15:02:13Z","timestamp":1700406133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajp.1016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,16]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1002\/ajp.1016"],"URL":"https:\/\/doi.org\/10.1002\/ajp.1016","archive":["Portico"],"relation":{},"ISSN":["0275-2565","1098-2345"],"issn-type":[{"value":"0275-2565","type":"print"},{"value":"1098-2345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5,16]]}}}