{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:28:08Z","timestamp":1770830888702,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":4902,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Primatol"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the occurrence of rickets in adolescent tamarins (<jats:italic>Saguinus imperator<\/jats:italic>) residing at the Los Angeles Zoo. Compared to tamarins in the same colony without clinical evidence of bone disease (N = 6), rachitic platyrrhines (N = 3) had a decrease in their serum calcium concentration (<jats:italic>P<\/jats:italic> &lt; .05). The affected tamarins also had lower serum 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> (1,25\u2010(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>) levels than did nonaffected colony mates, but 2\u201310\u2010fold higher concentrations than in Old World primates of a comparable developmental stage. New World primates in many different genera are known to exhibit target organ resistance to the active vitamin D<jats:sub>3<\/jats:sub> metabolite, 1,25\u2010(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>, compensated by maintenance of high circulating concentrations of 1,25\u2010(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>. The relatively low serum 1,25\u2010(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> concentration in rachitic tamarins and ultraviolet B radiation deficient environment of these primates suggested that bone disease may be linked to a deficiency in substrate for 1,25\u2010(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>, 25 hydroxyvtamin D<jats:sub>3<\/jats:sub> (25\u2010OHD<jats:sub>3<\/jats:sub>). Chronic exposure of platyrrhines in three different vitamin D resistant genera to an artificial UVB source resulted in 1) a significant increase in the mean serum 25\u2010OHD<jats:sub>3<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; .001) and 1,25\u2010(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; .02) level over that encountered in platyrrhines not exposed to UVB; and 2) prevention of rachitic bone disease in irradiated individuals. These data further show that the serum 25\u2010OHD<jats:sub>3<\/jats:sub> and 1,25\u2010OH<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> levels are positively correlated in vitamin D\u2010resistant platyrrhines (r = 0.64; <jats:italic>P<\/jats:italic>= .0014) and suggest that a compromise in cutaneous vitamin D<jats:sub>3<\/jats:sub> production by means of UVB deprivation may limit necessary 1,25\u2010(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> production. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajp.1350280404","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T02:18:54Z","timestamp":1118542734000},"page":"263-270","source":"Crossref","is-referenced-by-count":29,"title":["Influence of ultraviolet B radiation on vitamin D<sub>3<\/sub> metabolism in vitamin D<sub>3<\/sub>\u2010resistant New World primates"],"prefix":"10.1002","volume":"28","author":[{"given":"Mercedes A.","family":"Gacad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W.","family":"Deseran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)84221-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198203253061206"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.1350090307"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-116-6-2523"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.1350130407"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-1-224"},{"key":"e_1_2_1_8_1","first-page":"433","volume-title":"Pathology of Simian Primates","author":"Barker M. J. M.","year":"1972"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-3-383"},{"key":"e_1_2_1_10_1","first-page":"813","volume-title":"Vitamin D, Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism","author":"Endres D. B.","year":"1982"},{"key":"e_1_2_1_11_1","first-page":"70","volume-title":"Primer On The Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Endres D. B.","year":"1990"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-55-5-1020"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1152\/physrev.1980.60.2.551","article-title":"Regulation of the metabolism of vitamin D","volume":"60","author":"Eraser D. R.","year":"1980","journal-title":"Physiology Reviews"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115108"},{"key":"e_1_2_1_15_1","first-page":"155","volume-title":"Metabolic Bone Disease","author":"Holick M. F.","year":"1990"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110759"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(85)80338-0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114944"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-6-1282"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(87)90077-8"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(74)90241-1"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(83)90801-X"},{"key":"e_1_2_1_23_1","first-page":"1367","volume-title":"Endocrinology and Metabolism","author":"Stewart A. F.","year":"1987"}],"container-title":["American Journal of Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajp.1350280404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajp.1350280404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T15:02:06Z","timestamp":1698073326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajp.1350280404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/ajp.1350280404"],"URL":"https:\/\/doi.org\/10.1002\/ajp.1350280404","archive":["Portico"],"relation":{},"ISSN":["0275-2565","1098-2345"],"issn-type":[{"value":"0275-2565","type":"print"},{"value":"1098-2345","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}