{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T10:10:12Z","timestamp":1698228612298},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":4170,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Primatol"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study describes the peripheral concentrations of immunoreactive (ir) inhibin, progesterone, and bioactive gonadotrophin during pregnancy in the marmoset monkey, a New World primate. Blood samples were taken every two weeks from six animals from ovulation to parturition. Plasma ir\u2010inhibin concentrations were measured by inhibin \u03b1\u2010subunit\u2010directed radioimmunoassay (RIA) and a recently developed two\u2010site immunoradiometric assay (IRMA) which is specific for inhibin \u03b1\u03b2 dimer. Concentrations of \u03b1\u2010inhibin increased (<jats:italic>P<\/jats:italic> &lt; 0.001) during early pregnancy to reach a peak on week 12 of pregnancy and showed a positive correlation with bioassayable gonadotrophin concentrations (<jats:italic>r<\/jats:italic> = 0.5, n = 64; P &lt; 0.001). The concentrations of both \u03b1\u2010inhibin and gonadotrophin showed no further peaks and declined (<jats:italic>P<\/jats:italic> &lt; 0.001) to low levels prior to birth. Concentrations of dimeric inhibin were substantially lower than those measured by RIA and did not vary significantly during pregnancy. Progesterone concentrations remained at luteal\u2010phase levels during the first half of pregnancy and increased (P &lt; 0.05) during the second half to reach maximum concentrations just prior to birth. The relationship between \u03b1\u2010inhibin, gonadotrophin, and progesterone suggests that the increase in \u03b1\u2010inhibin may be luteal in source and under the control of gonadotrophin. The absence of a second increase in \u03b1\u2010inhibin later in pregnancy and the finding that lategestation placenta contained very little \u03b1\u2010inhibin differs from observations in Old World primates studied and suggests that the placenta may not be a source of inhibin during pregnancy in the marmoset. The finding of high levels of \u03b1\u2010inhibin, but not dimeric inhibin, suggests that inhibin\u2010related molecules may have a role other than suppression of pituitary folliclestimulating hormone. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajp.1350320305","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:49:16Z","timestamp":1118497756000},"page":"187-195","source":"Crossref","is-referenced-by-count":1,"title":["Changes in plasma concentrations of immunoreactive inhibin, progesterone, and bioactive gonadotrophin during pregnancy in the marmoset monkey"],"prefix":"10.1002","volume":"32","author":[{"given":"G. E.","family":"Webley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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