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In particular, experimentally induced fetal androgen excess in female rhesus monkeys produces a comprehensive adult PCOS\u2010like phenotype that includes both reproductive and metabolic dysfunction found in PCOS women. Such a reliable experimental approach enables the use of the prenatally androgenized (PA) female rhesus monkey model to (1) examine fetal, infant and adolescent antecedents of adult pathophysiology, gaining valuable insight into early phenotypic expression of PCOS, and (2) to understand adult pathophysiology from a mechanistic perspective. Elevated circulating luteinizing hormone (LH) levels are the earliest indication of reproductive dysfunction in late gestation nonhuman primate fetuses and infants exposed to androgen excess during early (late first to second trimester) gestation. Such early gestation\u2010exposed PA infants also are hyperandrogenic, with both LH hypersecretion and hyperandrogenism persisting in early gestation\u2010exposed PA adults. Similarly, subtle metabolic abnormalities appearing in young nonhuman primate infants and adolescents precede the abdominal adiposity, hyperliplidemia and increased incidence of type 2 diabetes that characterize early gestation\u2010exposed PA adults. These new insights into the developmental origins of PCOS, and progression of the pathophysiology from infancy to adulthood, provide opportunities for clinical intervention to ameliorate the PCOS phenotype thus providing a preventive health\u2010care approach to PCOS\u2010related abnormalities. For example, PCOS\u2010like traits in PA monkeys, as in PCOS women, can improve with better insulin\u2013glucose homeostasis, suggesting that lifestyle interventions preventing increased adiposity in adolescent daughters of PCOS mothers also may reduce their risk of acquiring many PCOS\u2010related metabolic abnormalities in adulthood. Am. J. Primatol. 71:776\u2013784, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajp.20679","type":"journal-article","created":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T14:38:40Z","timestamp":1239719920000},"page":"776-784","source":"Crossref","is-referenced-by-count":137,"title":["Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys"],"prefix":"10.1002","volume":"71","author":[{"given":"David H.","family":"Abbott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice F.","family":"Tarantal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Dumesic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"369","volume-title":"Androgen excess disorders in women","author":"Abbott DH","year":"1997"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(98)00019-8"},{"key":"e_1_2_1_4_1","first-page":"119","volume-title":"Polycystic ovary syndrome","author":"Abbott DH","year":"2002"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.45.2.116"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi013"},{"key":"e_1_2_1_7_1","first-page":"259","volume-title":"Contemporary endocrinology: androgen excess disorders in women: polycystic ovary syndrome and other disorders","author":"Abbott DH","year":"2006"},{"key":"e_1_2_1_8_1","unstructured":"AbbottDH GoodfriendTL DunaifA MullerSJ DumesicDA.2007.Increased body weight and enhanced insulin sensitivity in infant female rhesus monkeys exposed to androgen excess during early gestation. 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