{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:40:25Z","timestamp":1792608025621,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Primatol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>\n                    Two health problems have plagued captive common marmoset (\n                    <jats:italic>Callithrix jacchus<\/jats:italic>\n                    ) colonies for nearly as long as those colonies have existed: marmoset wasting syndrome and metabolic bone disease. While marmoset wasting syndrome is explicitly linked to nutrient malabsorption, we propose metabolic bone disease is also linked to nutrient malabsorption, although indirectly. If animals experience negative nutrient balance chronically, critical nutrients may be taken from mineral stores such as the skeleton, thus leaving those stores depleted. We indirectly tested this prediction through an initial investigation of digestive efficiency, as measured by apparent energy digestibility, and serum parameters known to play a part in metabolic bone mineral density of captive common marmoset monkeys. In our initial study on 12 clinically healthy animals, we found a wide range of digestive efficiencies, and subjects with lower digestive efficiency had lower serum vitamin D despite having higher food intakes. A second experiment on 23 subjects including several with suspected bone disease was undertaken to measure digestive and serum parameters, with the addition of a measure of bone mineral density by dual\u2010energy X\u2010ray absorptiometry (DEXA). Bone mineral density was positively associated with apparent digestibility of energy, vitamin D, and serum calcium. Further, digestive efficiency was found to predict bone mineral density when mediated by serum calcium. These data indicate that a poor ability to digest and absorb nutrients leads to calcium and vitamin D insufficiency. Vitamin D absorption may be particularly critical for indoor\u2010housed animals, as opposed to animals in a more natural setting, because vitamin D that would otherwise be synthesized via exposure to sunlight must be absorbed from their diet. If malabsorption persists, metabolic bone disease is a possible consequence in common marmosets. These findings support our hypothesis that both wasting syndrome and metabolic bone disease in captive common marmosets are consequences of inefficient nutrient absorption. Am. J. Primatol. 75:153\u2010160, 2013. \u00a9 2012 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajp.22093","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T11:37:00Z","timestamp":1353411420000},"page":"153-160","source":"Crossref","is-referenced-by-count":28,"title":["Digestive Efficiency Mediated by Serum Calcium Predicts Bone Mineral Density in the Common Marmoset (\n                    <i>Callithrix jacchus<\/i>\n                    )"],"prefix":"10.1002","volume":"75","author":[{"given":"MICHAEL R.","family":"JARCHO","sequence":"first","affiliation":[{"name":"Psychology Department University of California  Davis California"},{"name":"Cousins Center for Psychoneuroimmunology University of California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL L.","family":"POWER","sequence":"additional","affiliation":[{"name":"American College of Obstetricians and Gynecologists  Washington DC"},{"name":"Smithsonian Conservation Biology Institute Nutrition Laboratory  Washington DC"},{"name":"Conservation Ecology Center National Zoological Park  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DONNA G.","family":"LAYNE\u2010COLON","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center  San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUZETTE D.","family":"TARDIF","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center  San Antonio Texas"},{"name":"University of Texas Health Science Center at San Antonio  San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0530155"},{"key":"e_1_2_6_3_1","first-page":"55","volume-title":"Callitrichid nutrition","author":"Barnard D","year":"1993"},{"key":"e_1_2_6_4_1","first-page":"282","article-title":"The apparent reversal of a wasting syndrome by nutritional intervention in Saguinus mystax","volume":"38","author":"Barnard D","year":"1988","journal-title":"Lab Anim Sci"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.06.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02382462"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2001.tb00007.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.143.3.78"},{"key":"e_1_2_6_9_1","first-page":"148","volume-title":"Results of a preliminary survey into wasting marmoset syndrome in callitrichid collections","author":"Ialeggio DM","year":"1995"},{"key":"e_1_2_6_10_1","first-page":"1182","article-title":"Effect of vitamin D on intestinal calcium absorption","volume":"23","author":"Kocian J.","year":"1977","journal-title":"Vnitrni lekarstvi"},{"key":"e_1_2_6_11_1","first-page":"351","article-title":"Husbandry, handling and nutrition for marmosets","volume":"53","author":"Layne DG","year":"2003","journal-title":"Comp Med"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/019262339602400605"},{"key":"e_1_2_6_13_1","first-page":"369","article-title":"Clinical care and diseases of the common marmoset (Callithrix jacchus)","volume":"53","author":"Ludlage E","year":"2003","journal-title":"Comp Med"},{"key":"e_1_2_6_14_1","first-page":"1529","article-title":"25\u2010Hydroxy vitamin D deficiency with reduction of intestinal calcium absorption and bone density in chronic alcoholism","volume":"107","author":"Luisier M","year":"1977","journal-title":"Schweizerische medizinische Wochenschrift"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.20443"},{"key":"e_1_2_6_16_1","first-page":"32","volume-title":"Do new world primates really have elevated needs for protein and vitamin D?","author":"Oftedal OT","year":"1997"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.20737"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2361(1997)16:1<39::AID-ZOO6>3.0.CO;2-C"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06517.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.20715"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2361(1999)18:6<473::AID-ZOO2>3.0.CO;2-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555736"}],"container-title":["American Journal of Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajp.22093","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajp.22093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:40:18Z","timestamp":1696552818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajp.22093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,20]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1002\/ajp.22093"],"URL":"https:\/\/doi.org\/10.1002\/ajp.22093","archive":["Portico"],"relation":{},"ISSN":["0275-2565","1098-2345"],"issn-type":[{"value":"0275-2565","type":"print"},{"value":"1098-2345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,20]]}}}