{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:22:28Z","timestamp":1793179348131,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006757","name":"Office of Research and Creative Activities, Brigham Young University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006757","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Primatol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Identifying predictors of teenage alcohol use disorder (AUDs) is a major health initiative, with studies suggesting that there are distinct personality\u2010related traits that underlie patterns of alcohol intake. As temperament is biologically based, identifiable early in life, and stable across time, it is considered the foundation of personality. As such, we hypothesized that neonatal temperament traits would predict anxiety\u2010mediated adolescent alcohol consumption. To test this, <jats:italic>N\u2009<\/jats:italic>=\u2009145 rhesus macaque (<jats:italic>Macaca mulatta<\/jats:italic>) infants (14 days of age), reared in a neonatal nursery (<jats:italic>n\u2009<\/jats:italic>=\u200982) or in a control condition with their mothers (<jats:italic>n\u2009<\/jats:italic>=\u200963) were assessed with a widely used standardized nonhuman primate testing battery, the Infant Behavioral Assessment Scale (IBAS), modeled after the Brazelton Neonatal Assessment Scale, evaluating visual orienting, temperament, motor maturity and, more recently, sensory sensitivity. As adolescents (3\u20134 years of age), these same subjects were allowed unfettered access to a sweetened\u2010alcohol solution for 1\u2009hr\/day, 4 days\/week, over 5\u20137 weeks. Subjects were allowed to self\u2010administer alcohol while housed alone (<jats:italic>n\u2009<\/jats:italic>=\u200970) or socially in their home cage (<jats:italic>n\u2009<\/jats:italic>=\u200955). Linear regressions showed that alcohol intake was predicted by neonatal orienting ability (<jats:italic>\u03b2\u2009<\/jats:italic>=\u2009\u2212.35; <jats:italic>p\u2009<\/jats:italic>=\u2009.01), state control (<jats:italic>\u03b2\u2009<\/jats:italic>=\u2009\u2212.19; <jats:italic>p\u2009<\/jats:italic>=\u2009.04), and motor maturity (<jats:italic>\u03b2\u2009<\/jats:italic>=\u2009\u2212.24; <jats:italic>p\u2009<\/jats:italic>=\u2009.01). Poor neonatal orienting, state control (ease of consolability), and motor maturity were associated with higher adolescent alcohol intake in rhesus monkeys. These findings suggest that neonatal temperament is predictive of patterns of adolescent alcohol intake. To the extent that these results generalize to humans, they provide evidence that early\u2010life temperament and neurodevelopment may be important risk factors for adolescent AUDs and that the IBAS may be used as an assessment tool for identifying such risk.<\/jats:p>","DOI":"10.1002\/ajp.23043","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T12:34:21Z","timestamp":1568896461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neonatal temperament and neuromotor differences are predictive of adolescent alcohol intake in rhesus monkeys (<i>Macaca mulatta<\/i>)"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-295X","authenticated-orcid":false,"given":"Elizabeth K.","family":"Wood","sequence":"first","affiliation":[{"name":"Department of Psychology Brigham Young University Provo Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribeth","family":"Champoux","sequence":"additional","affiliation":[{"name":"Center for Scientific Review, Division of AIDS, Behavior and Population Sciences NIH Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Lindell","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Studies National Institute on Alcohol Abuse and Alcoholism, NIH Bethesda Maryland"},{"name":"Section of Comparative Behavioral Genomics National Institute on Alcohol Abuse and Alcoholism, NIH Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina S.","family":"Barr","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Studies National Institute on Alcohol Abuse and Alcoholism, NIH Bethesda Maryland"},{"name":"Section of Comparative Behavioral Genomics National Institute on Alcohol Abuse and Alcoholism, NIH Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Suomi","sequence":"additional","affiliation":[{"name":"Section of Comparative Ethology Eunice Shriver Kennedy National Institute of Child Health and Human Development, NIH Poolesville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3745-3893","authenticated-orcid":false,"given":"J. 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