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Translational models to identify modifiable risk factors are needed to understand etiology and identify therapeutic targets. Here, we outline the evidence supporting the vervet monkey (<jats:italic>Chlorocebus aethiops sabaeus<\/jats:italic>) as a model of aging\u2010related AD\u2010like neuropathology and associated phenotypes including cognitive function, physical function, glucose handling, intestinal physiology, and CSF, blood, and neuroimaging biomarkers. This review provides the most comprehensive multisystem description of aging in vervets to date. This review synthesizes a large body of evidence that suggests that aging vervets exhibit a coordinated suite of traits consistent with early AD and provide a powerful, naturally occurring model for LOAD. Notably, relationships are identified between AD\u2010like neuropathology and modifiable risk factors. Gaps in knowledge and key limitations are provided to shape future studies to illuminate mechanisms underlying divergent neurocognitive aging trajectories and to develop interventions that increase resilience to aging\u2010associated chronic disease, particularly, LOAD.<\/jats:p>","DOI":"10.1002\/ajp.23260","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T11:25:37Z","timestamp":1617621937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Aging\u2010related Alzheimer's disease\u2010like neuropathology and functional decline in captive vervet monkeys (<i>Chlorocebus aethiops sabaeus<\/i>)"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8818-063X","authenticated-orcid":false,"given":"Brett M.","family":"Frye","sequence":"first","affiliation":[{"name":"Department of Pathology\/Comparative Medicine Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"},{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-8657","authenticated-orcid":false,"given":"Suzanne","family":"Craft","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"},{"name":"Wake Forest Alzheimer's Disease Research Center Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"},{"name":"J. 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