{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:57:38Z","timestamp":1791201458199,"version":"4.2.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AG060931"],"award-info":[{"award-number":["R01\u2010AG060931"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P40\u2010OD012217"],"award-info":[{"award-number":["P40\u2010OD012217"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Primatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Free\u2010ranging rhesus macaques (Macaca mulatta) on Cayo Santiago provide a uniquely characterized translational model for periodontal disease, supported by decades of demographic and genetic data. To assess the feasibility of conducting comprehensive periodontal examinations, oral biospecimen collection, and portable intraoral radiography in free\u2010ranging macaques during a 5\u2010day pilot field campaign. Eighteen macaques (7 males, 11 females; ages 9\u201323 years) were evaluated under ketamine\/xylazine anesthesia. Periodontal charting (probing depth, clinical attachment level, bleeding on probing), multimodal biospecimen collection (gingival crevicular fluid, tongue swabs, supragingival plaque, whole saliva), and portable intraoral radiography (KaVo NOMAD Pro 2) were performed within an existing multi\u2010station sedation workflow. Full periodontal assessments were completed in 18\/22 animals (82%). Mean probing depths were 2.0\u20132.2\u2009mm, with significantly greater depths in aged animals (\u2265\u200915 years;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). GCF RNA and protein yields were inadequate for planned analyses. Tongue swabs from 15 animals yielded sufficient protein for 37\u2010analyte multiplex profiling; 31 analytes met the minimum criterion for age\u2010group comparisons. Exploratory analysis identified higher CD40L and IL\u20108\/CXCL8 in aged animals and modest difference in TNF\u2010\u03b1.\u00a0Age\u2010by\u2010sex interactions were identified for IL\u20108\/CXCL8 and IP\u201010\/CXCL10. Radiographs showed age\u2010related alveolar bone loss without caries. Comprehensive oral health assessment is feasible in this field setting. Earlier dental\u2010station placement and improved GCF collection are needed. Tongue swabs offer a practical specimen for inflammatory profiling, supporting future longitudinal oral health phenotyping within the established Cayo Santiago infrastructure.\n                  <\/jats:p>","DOI":"10.1002\/ajp.70210","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:21:34Z","timestamp":1791199294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of Field Oral Health Assessment in Free\u2010Ranging Rhesus Macaques (Macaca mulatta) on Cayo Santiago"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-8608","authenticated-orcid":false,"given":"Jonathan Y.","family":"An","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences, School of Dentistry University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, School of Dentistry University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Nordlie","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dentistry University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dentistry University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-1069","authenticated-orcid":false,"given":"Josu\u00e9 E.","family":"Negr\u00f3n\u2010Del Valle","sequence":"additional","affiliation":[{"name":"Center for Evolution and Medicine Arizona State University Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Phillips","sequence":"additional","affiliation":[{"name":"Center for Evolution and Medicine Arizona State University Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahiri","family":"Rivera","sequence":"additional","affiliation":[{"name":"Caribbean Primate Research Center University of Puerto Rico San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0733-4110","authenticated-orcid":false,"given":"Angelina Ruiz","family":"Lambides","sequence":"additional","affiliation":[{"name":"Caribbean Primate Research Center University of Puerto Rico San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-6160","authenticated-orcid":false,"given":"Noah","family":"Snyder\u2010Mackler","sequence":"additional","affiliation":[{"name":"Center for Evolution and Medicine Arizona State University Tempe Arizona USA"},{"name":"School of Life Sciences Arizona State University Tempe Arizona USA"},{"name":"School of Human Evolution and Social Change Arizona State University Tempe Arizona USA"},{"name":"ASU\u2010Banner Neurodegenerative Disease Research Center Arizona State University Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201033950\u20106"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010022\u201001197\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2019.0612"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12135"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2022.817249"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.23724"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.64.7.3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.22376"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00067\u201019"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105424"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11282\u2010020\u201000434\u20101"},{"key":"e_1_2_10_13_1","unstructured":"R: A Language and Environment for Statistical Computing; R Foundation for Statistical Computing: Vienna Austria 2025.https:\/\/www.R\u2010project.org\/."},{"key":"e_1_2_10_14_1","volume-title":"R: A language and environment for statistical computing","author":"RCoreTeam","year":"2017"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.03.029"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.24920"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.24901"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.22424"}],"container-title":["American Journal of Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajp.70210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajp.70210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajp.70210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:21:35Z","timestamp":1791199295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajp.70210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ajp.70210"],"URL":"https:\/\/doi.org\/10.1002\/ajp.70210","archive":["Portico"],"relation":{},"ISSN":["0275-2565","1098-2345"],"issn-type":[{"value":"0275-2565","type":"print"},{"value":"1098-2345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70210"}}