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In this study, high\u2010resolution magnetic resonance imaging was used to measure regional brain volumes in 46 normal, right\u2010handed adults (23 men, 23 women) between the ages of 22\u201349 years. Parcellation of the brain was based on neuroanatomical landmarks. The following brain regions were measured: the cerebral hemispheres, frontal lobe, temporal lobe, parietal lobe, occipital lobe, cingulate gyrus, insula, cerebellum, corpus callosum, and lateral ventricles. Males tend to be significantly larger than females, for the whole brain and for nearly all of its major subdivisions, including the corpus callosum. However, the proportional sizes of regions relative to total volume of the hemisphere are remarkably similar in males and females. Variation in size of region is always greater than variation in proportional representation. Asymmetries in brain regions are not profound, with the exception of the cingulate gyrus, which is larger in the left hemisphere. Brain regions are highly correlated in size, with the exception of the lateral ventricles. After controlling for hemisphere size, the volumes of the frontal and parietal lobes are significantly negatively correlated. The occipital lobe tends to be less sexually dimorphic than other major lobes, and less correlated with other brain regions for volume. These results have implications for understanding whether or not certain sectors of the brain have shown relative expansion over the course of hominid and hominoid evolution. Am J Phys Anthropol 118:341\u2013358, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajpa.10092","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T02:05:28Z","timestamp":1031709928000},"page":"341-358","source":"Crossref","is-referenced-by-count":244,"title":["Normal neuroanatomical variation in the human brain: An MRI\u2010volumetric study"],"prefix":"10.1002","volume":"118","author":[{"given":"John S.","family":"Allen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Damasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Grabowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,7,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.1.130"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199601000-00018"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.9.816"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.2.257"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(96)00049-8"},{"key":"e_1_2_1_7_1","volume-title":"An introduction to medical statistics","author":"Bland M","year":"2000"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(19991215)257:6<217::AID-AR7>3.0.CO;2-W"},{"key":"e_1_2_1_9_1","volume-title":"Localisation in the cerebral cortex","author":"Brodmann K","year":"1999"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.8.4.563"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(99)00022-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902800205"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00358-7"},{"key":"e_1_2_1_14_1","first-page":"672","article-title":"Normal brain development and aging: quantitative analysis and in vivo MR imaging in healthy volunteers","volume":"216","author":"Courchesne E","year":"2000","journal-title":"Neuroradiology"},{"key":"e_1_2_1_15_1","volume-title":"Human brain anatomy in computerized images","author":"Damasio H","year":"1995"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530260037016"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/8.7.635"},{"key":"e_1_2_1_18_1","volume-title":"The symbolic species","author":"Deacon T","year":"1997"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1126\/science.7089533","article-title":"Sexual dimorphism in the human corpus callosum","volume":"216","author":"de Lacoste\u2010Utamsing C","year":"1982","journal-title":"Science"},{"key":"e_1_2_1_20_1","volume-title":"The human brain","author":"Duvernoy H","year":"1991"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(94)90283-6"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330530409"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330840109"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/jhev.1998.0273"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7777856"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X01003958"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0250"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/6.4.551"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.6.537"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0649"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-04065.1999"},{"key":"e_1_2_1_32_1","first-page":"635","article-title":"Analysis of brain weight. 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