{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:16:23Z","timestamp":1756991783538},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T00:00:00Z","timestamp":1115078400000},"content-version":"vor","delay-in-days":7276,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[1985,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This paper presents an image enhancement and analysis system (DARWIN) based on an inexpensive microcomputer and applies the system to two bone morphometry problems relevant to postmenopausal osteoporosis. Using ovariectomized and intact female <jats:italic>Macaca fascicularis<\/jats:italic> as a model, we examined the radiodensity of the sixth lumbar vertebra and the cross\u2010section area of the right femur. Significantly lower bone density was observed in the vertebral segments of the ovariectomized animals. No significant differences were observed in comparisons of the femoral cross sections. The reduction in radiographic density of the ovariectomized animals' vertebrae is similar to that observed in postmenopausal women, supporting the use of female cynomolgus macaques as models of bone loss in postmenopausal osteoporosis.<\/jats:p>","DOI":"10.1002\/ajpa.1330670204","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T07:38:52Z","timestamp":1139038732000},"page":"99-103","source":"Crossref","is-referenced-by-count":23,"title":["Bone measurement by enhanced contrast image analysis: Ovariectomized and intact <i>Macaca fascicularis<\/i> as a model for human postmenopausal osteoporosis"],"prefix":"10.1002","volume":"67","author":[{"given":"E. A.","family":"Bowles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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Consensus Development Conference Statement Vol. 5 No. 3. Bethesda: NIH.","DOI":"10.7863\/jum.1984.3.5.r54"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1982.tb01288.x"},{"key":"e_1_2_1_11_1","volume-title":"Bone Histomorphometry: Techniques and Interpretation","author":"Smith JM","year":"1983"},{"key":"e_1_2_1_12_1","first-page":"228","article-title":"Use of histology in ancient bone research","volume":"22","author":"Stout S","year":"1979","journal-title":"Yrbk. Phys. Anthropol."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-42-3-537"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.72.1.177"},{"key":"e_1_2_1_15_1","first-page":"269","article-title":"A model for post\u2010menopausal osteoporosis using Macaca fascicularis","volume":"60","author":"Weaver DS","year":"1983","journal-title":"Am. J. Phys. 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