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Analysis focused on 54 subadults aged 0\u201310 years at death from the Arroyo Hondo site. Early age of onset is documented in the pattern of coincident active periosteal reactions and porotic lesions under 6 months. Endemically inadequate diets affecting pregnant females and their fetuses, acting synergistically with immediately acquired infections, not weaning diets, are the probable major underlying causes for the early onset of iron\u2010deficiency anemia at Arroyo Hondo.<\/jats:p>","DOI":"10.1002\/ajpa.1330740411","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T04:53:11Z","timestamp":1139028791000},"page":"527-537","source":"Crossref","is-referenced-by-count":41,"title":["Endemic disease patterns in Paleopathology: Porotic hyperostosis"],"prefix":"10.1002","volume":"74","author":[{"given":"Ann M.","family":"Palkovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1182\/blood.V27.5.677.677","article-title":"Roentgeno\u2010graphic bones in chronic iron deficiency anemia","volume":"27","author":"Aksoy M","year":"1966","journal-title":"Blood"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1966.02090040081007"},{"key":"e_1_2_1_4_1","volume-title":"A Basic Course in Statistics","author":"Anderson T","year":"1975"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330220342"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.153.3737.760"},{"key":"e_1_2_1_7_1","volume-title":"Diseases in Antiquity","author":"Angel JL","year":"1967"},{"key":"e_1_2_1_8_1","series-title":"Paleopathology Monograph No. 2","volume-title":"Porotic hyperostosis: An Enquiry","author":"Angel JL","year":"1977"},{"key":"e_1_2_1_9_1","volume-title":"Paleoepidemiology","author":"Angel JL","year":"1978"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.163.3864.255"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91165-2"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330660404"},{"key":"e_1_2_1_13_1","volume-title":"Iron Metabolism","author":"Bothwell T","year":"1962"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.62.6.773"},{"key":"e_1_2_1_15_1","first-page":"201","article-title":"Intravenous iron loadings of patients with infections","volume":"239","author":"Brendstrup P","year":"1950","journal-title":"Acta Med. 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