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It is found at a fairly early age in adult males in this group, but in females it does not appear until after age 40 years. Spondylolysis is associated with higher levels of osteoarthritis around the fifth lumbar vertebra, where this defect typically occurs. Otherwise, there is little relationship between its presence and degenerative joint disease, especially in the weight\u2010bearing joints. The incidence in young males may be related to activities necessitating a high level of mobility around the lumbar spine. The late occurrence in females suggests that osteoporosis may have been a contributing factor.<\/jats:p>","DOI":"10.1002\/ajpa.1330790308","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T04:48:36Z","timestamp":1139028516000},"page":"321-329","source":"Crossref","is-referenced-by-count":25,"title":["Spondylolysis and its relationship to degenerative joint disease in the prehistoric Southeastern United States"],"prefix":"10.1002","volume":"79","author":[{"given":"Patricia S.","family":"Bridges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,27]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"BridgesPS(1985)Changes in long bone structure with the transition to agriculture: Implications for prehistoric activities. 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