{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:58:07Z","timestamp":1772819887484,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,2]],"date-time":"2005-05-02T00:00:00Z","timestamp":1114992000000},"content-version":"vor","delay-in-days":4688,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the combination of polymorphic restriction\u2010enzyme sites in the \u03b2 globin gene cluster (haplotypes) for 74 chromosomes from Brazilian Blacks bearing the sickle hemoglobin gene (\u03b2<jats:sup>s<\/jats:sup>). The three most common African \u03b2<jats:sup>s<\/jats:sup> haplotypes account for 67 chromosomes: 49\/74 (66.2%) were identified as Central African Republic (CAR or Bantu) type, 17 (23.0%) as Benin, and one as Senegal; seven chromosomes (9.5%) had minor atypical haplotypes. This distribution is different from that observed in the United States or Jamaica, where the Benin haplotype predominates, and results from different patterns of slave trades to North and South Americas. Since the \u03b2<jats:sup>s<\/jats:sup> gene cluster polymorphisms modulate the severity of sickle cell anemia, this heterogeneity may explain differences of the clinical behavior of the disease in the United States and South America, and should also be considered in relation to other features and diseases. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajpa.1330880304","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T10:17:30Z","timestamp":1139048250000},"page":"295-298","source":"Crossref","is-referenced-by-count":53,"title":["Bantu \u03b2<sup>s<\/sup> cluster haplotype predominates among Brazilian Blacks"],"prefix":"10.1002","volume":"88","author":[{"given":"Marco A.","family":"Zago","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro S.","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satie H.","family":"Ogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4857.290"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.3.853"},{"key":"e_1_2_1_4_1","volume-title":"The Slave Atlantic Trade: A Census","author":"Curtin PD","year":"1969"},{"key":"e_1_2_1_5_1","first-page":"605","article-title":"Deletion type \u03b1\u2010thalassemia among Brazilian patients with sickle cell anemia","volume":"12","author":"Costa FF","year":"1989","journal-title":"Rev. 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