{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:55:28Z","timestamp":1791341728779,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,3,18]],"date-time":"2008-03-18T00:00:00Z","timestamp":1205798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rapid diagnostic test (RDT) that detects <jats:italic>Yersinia pestis<\/jats:italic> F1 antigen was applied to 28 putative plague victims exhumed from seven burial sites in southeastern France dating to the 16th\u201318th centuries. <jats:italic>Yersinia pestis<\/jats:italic> F1 antigen was detected in 19 of the 28 (67.9%) samples. The 27 samples used as negative controls yielded negative results. Soil samples taken from archeological sites related to both positive and negative samples tested negative for F1 antigen. The detection threshold of the RDT for plague (0.5 ng\/ml) is sufficient for a preliminary retrospective diagnosis of <jats:italic>Y. pestis<\/jats:italic> infection in human remains. The high specificity and sensitivity of the assay were confirmed. For two sites positive to F1 antigen (Lambesc and Marseille), <jats:italic>Y. pestis<\/jats:italic>\u2010specific DNA (<jats:italic>pla<\/jats:italic> gene) had been identified previously by PCR\u2010sequence based analyses. Specifically, the positive results for two samples, from the Lambesc cemetery and the Marseille pit burial, matched those previously reported using PCR. Independent analyses in Italy and France of different samples taken from the same burial sites (Draguignan and Martigues) led to the identification of both <jats:italic>Y. pestis<\/jats:italic> F1 antigen and <jats:italic>Y. pestis pla<\/jats:italic> and <jats:italic>gplD<\/jats:italic> genes. These data are clear evidence of the presence of <jats:italic>Y. pestis<\/jats:italic> in the ancient human remains examined in this study. Am J Phys Anthropol, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajpa.20818","type":"journal-article","created":{"date-parts":[[2008,3,18]],"date-time":"2008-03-18T22:16:31Z","timestamp":1205878591000},"page":"361-367","source":"Crossref","is-referenced-by-count":51,"title":["Technical note: A rapid diagnostic test detects plague in ancient human remains: An example of the interaction between archeological and biological approaches (southeastern France, 16th\u201318th centuries)"],"prefix":"10.1002","volume":"136","author":[{"given":"Raffaella","family":"Bianucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Rahalison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Rabino","family":"Massa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Ferroglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Signoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20243"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvi.2007.07.007"},{"key":"e_1_2_1_4_1","volume-title":"Les hommes et la peste en France et dans les pays europ\u00e9ens et m\u00e9diterran\u00e9ens","author":"Biraben J\u2010N","year":"1975"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4000\/books.editionscnrs.8739","volume-title":"La saison d'une peste (avril\u2010septembre 1590): le cimeti\u00e8re des F\u00e9dons \u00e0 Lambesc","author":"Bizot B","year":"2005"},{"key":"e_1_2_1_6_1","first-page":"5","volume-title":"Endodontie clinique","author":"Brouillet JL","year":"1986"},{"key":"e_1_2_1_7_1","first-page":"21","article-title":"Etude d'ADN ancien au niveau de la pulpe dentaire de la s\u00e9rie ost\u00e9ologique de Saint C\u00f4me et Damien","volume":"1","author":"Calvo L","year":"2001","journal-title":"Anthropo"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12270-2"},{"key":"e_1_2_1_9_1","first-page":"171","article-title":"Vieillissement physiologique et cavit\u00e9 buccale","volume":"2","author":"Clergeau\u2010Gueritault S","year":"1991","journal-title":"R\u00e9alit\u00e9s Clin"},{"key":"e_1_2_1_10_1","unstructured":"DevriendtW ArdagnaY SignoliM.2001.Etude anthropologique des ossements humains d\u00e9couverts au lieu dit \u2018La Butte aux Herbes\u2019 (Draguignan Var). UMR 6578 CNRS\/Universit\u00e9 de la M\u00e9diterran\u00e9e\u2010Service de Anthropologie Biologique Facult\u00e9 de M\u00e9decine de Marseille. p15."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12637"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01515-5"},{"key":"e_1_2_1_13_1","first-page":"23","article-title":"Palaeomicrobiology: current issues and perspectives","volume":"3","author":"Drancourt M","year":"2005","journal-title":"Microbiol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1009.030933"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1302.060197"},{"key":"e_1_2_1_16_1","first-page":"104","article-title":"Two\u2010digit system of designation of teeth","volume":"21","author":"F\u00e9d\u00e9ration Dentaire Internationale (FDI)","year":"1971","journal-title":"Int Dent J"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26594-0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/280601"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.3406\/bmsap.1996.2458"},{"key":"e_1_2_1_20_1","first-page":"35","volume-title":"L'enfant, son corps, son histoire. Actes des Septi\u00e8mes Journ\u00e9es Anthropologiques de Valbonne 1\u20133 juin 1994","author":"Guy H","year":"1997"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1212(199705)7:3<221::AID-OA338>3.0.CO;2-Z"},{"key":"e_1_2_1_22_1","first-page":"43","volume-title":"Death, decay and reconstruction. Approaches to archaeology and forensic science","author":"Henderson JH","year":"1987"},{"key":"e_1_2_1_23_1","volume-title":"Endodontie clinique","author":"Laurichesse JM","year":"1986"},{"key":"e_1_2_1_24_1","volume-title":"Vertebrate taphonomy","author":"Lyman RL","year":"1996"},{"key":"e_1_2_1_25_1","first-page":"333","volume-title":"L'homme hier et aujourd'hui. Recueil d'\u00e9tudes en homage \u00e0 Andr\u00e9 Leroy\u2010Gourhan","author":"Masset C","year":"1973"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345680470031201"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60566-2"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01099-0"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.220225197"},{"key":"e_1_2_1_30_1","volume-title":"The dental pulp","author":"Seltzer S","year":"1984"},{"key":"e_1_2_1_31_1","volume-title":"Dental pulp","author":"Seltzer S","year":"2002"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.10308"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/ajpa.10024","article-title":"Paleohistology of bone: a new approach to the study of ancient diseases","volume":"44","author":"Schultz M","year":"2001","journal-title":"Am J Phys Anthropol"},{"key":"e_1_2_1_34_1","series-title":"Brit Arch Rep Int Ser","first-page":"156","volume-title":"Etudes anthropologiques des crises d\u00e9mographiques en contexte \u00e9pid\u00e9mique: Aspects pal\u00e9o\u2010 et biod\u00e9mographiques de la peste en Provence","author":"Signoli M","year":"2006"},{"key":"e_1_2_1_35_1","first-page":"119","volume-title":"La pal\u00e9od\u00e9mographie: m\u00e9moire d'os, m\u00e9moire d'hommes. Actes des Huiti\u00e8mes Journ\u00e9es Anthropologiques de Valbonne","author":"Signoli M","year":"2006"},{"key":"e_1_2_1_36_1","first-page":"7","article-title":"Marseille, 1722: le charnier de l'Observance et la rechute \u00e9pid\u00e9mique de la Grande Peste","volume":"58","author":"Signoli M","year":"1998","journal-title":"Med Trop"},{"key":"e_1_2_1_37_1","first-page":"173","article-title":"Etude anthropologique d'un charnier de la peste de 1720\u20131721 \u00e0 Martigues","volume":"4","author":"Signoli M","year":"1995","journal-title":"Pr\u00e9hist Anthropol M\u00e9dit"},{"key":"e_1_2_1_38_1","unstructured":"SignoliM GenotA ArdagnaY.2000.Etude anthropologique des squelettes d\u00e9couverts pr\u00e8s de la Chapelle de Notre\u2010Dame\u2010de\u2010Caderot (Berre L'Etang Bouches\u2010du\u2010Rh\u00f4ne). UMR 6578 CNRS\u2010Universit\u00e9 de la M\u00e9diterran\u00e9e\u2010 Facult\u00e9 de M\u00e9decine de Marseille\u2010 Service d'Anthropologie Biologique. p20."},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.36253\/978-88-8453-489-7","volume-title":"LA PESTE: entre \u00e9pid\u00e9mies et soci\u00e9t\u00e9s","author":"Signoli M","year":"2007"},{"key":"e_1_2_1_40_1","unstructured":"TzortzisS RigeadeC ArdagnaY DevriendtW SignoliM.2005.Les Tranch\u00e9es des Capucins des Ferri\u00e8res de Martigues: un charnier de la Grande Peste de 1720\u20131722 en Provence. Document final de synth\u00e8se. Ville de Martigues\u2010Service Arch\u00e9ologie. UMR 6578 CNRS\u2010Universit\u00e9 de la M\u00e9diterran\u00e9e\u2010Service R\u00e9gional de l'Arch\u00e9ologie Provence\u2010Alpes\u2010C\u00f4te d'Azur."},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330760206"},{"key":"e_1_2_1_42_1","volume-title":"Dental anatomy. Physiology and occlusion","author":"Wheeler RC","year":"1974"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.10276"}],"container-title":["American Journal of Physical Anthropology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajpa.20818","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajpa.20818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T17:52:21Z","timestamp":1696787541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajpa.20818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,18]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/ajpa.20818"],"URL":"https:\/\/doi.org\/10.1002\/ajpa.20818","archive":["Portico"],"relation":{},"ISSN":["0002-9483","1096-8644"],"issn-type":[{"value":"0002-9483","type":"print"},{"value":"1096-8644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,18]]}}}