{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:44:17Z","timestamp":1778165057536,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T00:00:00Z","timestamp":1219017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Arrest in long bone growth and the subsequent resumption of growth may be visible as radiopaque transverse lines in radiographs (Harris lines, HL; Harris, HA. 1933. Bone growth in health and disease. London: Oxford University Press). The assessment of individual age at occurrence of such lines, as part of paleopathological skeletal studies, is time\u2010consuming and shows large intra\u2010 and interobserver variability. Thus, a standardized, automated detection algorithm would help to increase the validity of such paleopathological research. We present an image analysis application facilitating automatic detection of HL. On the basis of established age calculation methods, the individual age\u2010at\u2010formation can be automatically assessed with the tool presented. Additional user input to confirm the automatic result is possible via an intuitive graphical user interface. Automated detection of HL from digital radiographs of a sample of late Medieval Swiss tibiae was compared to the consensus of manual assessment by two blinded expert observers. The intra\u2010 and interobserver variability was high. The quality of the observer result improved when standardized detection criteria were defined and applied. The newly developed algorithm detected two\u2010thirds of the HL that were identified as consensus lines between the observers. It was, however, necessary to validate the last one\u2010third by manual editing. The lack of a large test series must be noted. The application is freely available for further testing by any interested researcher. Am J Phys Anthropol, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajpa.20901","type":"journal-article","created":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T20:47:31Z","timestamp":1219092451000},"page":"362-366","source":"Crossref","is-referenced-by-count":11,"title":["Technical note: Standardized and semiautomated Harris lines detection"],"prefix":"10.1002","volume":"137","author":[{"given":"S.","family":"Suter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Harders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Papageorgopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sz\u00e9kely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.J.","family":"R\u00fchli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"393","article-title":"Reevaluating Harris lines\u2013\u2013a comparison between Harris lines and enamel hypoplasia","volume":"29","author":"Alfonso MP","year":"2005","journal-title":"Coll Antropol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330400313"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196345010-00001"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330850314"},{"key":"e_1_2_1_6_1","first-page":"283","article-title":"Reliability assessment of transverse lines","volume":"60","author":"Clark GA","year":"1988","journal-title":"Hum Biol"},{"key":"e_1_2_1_7_1","first-page":"77","article-title":"The association of early childhood enamel hypoplasias an radiopaque transverse lines in a culturally diverse prehistoric skeletal sample","volume":"54","author":"Clarke SK","year":"1982","journal-title":"Hum Biol"},{"key":"e_1_2_1_8_1","first-page":"364","article-title":"Transverse lines in X\u2010ray plates of long bones in children","volume":"41","author":"Eliot M","year":"1927","journal-title":"Bull John Hopkins Hosp"},{"key":"e_1_2_1_9_1","first-page":"58","article-title":"Lines and bands of increased density: their implication to growth and development","volume":"44","author":"Garn SM","year":"1968","journal-title":"Med Radiogr Photogr"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330310104"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2007.06.001"},{"key":"e_1_2_1_12_1","first-page":"35","volume-title":"Research report no. 20","author":"Goodman AH","year":"1981"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(199706)103:2<209::AID-AJPA6>3.0.CO;2-O"},{"key":"e_1_2_1_14_1","volume-title":"Bone growth in health and disease","author":"Harris HA","year":"1933"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330660307"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.3.260"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"KollerT GerigG Sz\u00e9kelyG DettwilerD.1995.Multiscale detection of curvilinear structures in 2D and 3D image data. 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