{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:37:15Z","timestamp":1762101435179},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T00:00:00Z","timestamp":1370908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The aim of this study is to explore the effect of prenatal androgenization on the clinical eruption of permanent teeth expressing dimorphism and bimaturism. The eruption curves of permanent teeth (except third molars), including those that make up the canine complex (permanent canines, lower first premolars), are compared among opposite sex twins (OS twins) relative to single\u2010born boys and girls. The comparisons are made with regard to three phases of eruption (pierced mucosa, half\u2010 erupted, and completely erupted) from a cross\u2010sectional sample of dental casts, using Kaplan\u2013Meier survival and Cox regression analyzes. The casts were collected from 2159 school children from the US Collaborative Perinatal Project, including 39 pairs of OS\u2010twins, of which 12 pairs (30.8%) were Euro\u2010Americans and 27 pairs (69.2%) were of African\u2010American ancestry. The eruption patterns of the incisors, upper first molars, and lower canines were found to be significantly masculinized (delayed) among OS twin girls. The differences in most other teeth were either not significant, or the number of observations of active eruption phases were too few, such as in the upper first molars and incisors, to yield strong evidence and meaningful results. The masculinization of the tooth eruption pattern in OS twin girls is intriguing because of the lower canine responses during puberty, as well as canine primordial formation during early fetal androgenization of their co\u2010twin during the 8th to 14th gestational weeks. The present results offer a challenge for future research exploring tooth eruption mechanisms, and may also highlight some cases of delayed or ectopic canines, which are biased toward females. Am J Phys Anthropol 151:566\u2013572, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajpa.22298","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T08:55:19Z","timestamp":1370940919000},"page":"566-572","source":"Crossref","is-referenced-by-count":9,"title":["Masculinization of the eruption pattern of permanent mandibular canines in opposite sex twin girls"],"prefix":"10.1002","volume":"151","author":[{"given":"Tuomo","family":"Heikkinen","sequence":"first","affiliation":[{"name":"Oral Development and Orthodontics Institute of Dentistry University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virpi","family":"Harila","sequence":"additional","affiliation":[{"name":"Oral Development and Orthodontics Institute of Dentistry University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha S.","family":"Tapanainen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lassi","family":"Alvesalo","sequence":"additional","affiliation":[{"name":"Oral Development and Orthodontics Institute of Dentistry University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,11]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"3","article-title":"The influence of sex\u2010chromosome genes on tooth size in man","volume":"67","author":"Alvesalo L","year":"1971","journal-title":"Proc Finn Dent Soc"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.06.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700606"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(80)90226-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2003.07.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.11.004"},{"key":"e_1_2_8_8_1","first-page":"710","article-title":"Spatial ability in members of opposite\u2010sex twin pairs","volume":"18","author":"Cole\u2010Harding S","year":"1988","journal-title":"Behav Genet"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1998.0171"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100514"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345800590070301"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6300(199909\/10)11:5<577::AID-AJHB1>3.0.CO;2-Y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1520\/JFS12897J","article-title":"A discriminant function analysis of deciduous teeth to determine sex","volume":"35","author":"Vito C","year":"1990","journal-title":"J Forensic Sci"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-6480(03)00216-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(71)90954-9"},{"key":"e_1_2_8_16_1","first-page":"51","article-title":"Eruption times of the deciduous and permanent teeth of natives on Bougainville Island, territory of New Guinea. A study of racial variation","volume":"41","author":"Friedlaender JS","year":"1969","journal-title":"Hum Biol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00001648-200005000-00020","article-title":"Strength and anthropometric measures in identical and fraternal twins: no evidence of masculinization of females with male co\u2010twins","volume":"11","author":"Gaist D","year":"2000","journal-title":"Epidemiology"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(67)90076-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345670460055801"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330510416"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/2121501b0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060060019009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345670460054001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.21047"},{"key":"e_1_2_8_25_1","volume-title":"The formation and the alveolar and clinical eruption of the permanent teeth [Thesis]","author":"Haavikko K","year":"1970"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/6.1.55"},{"key":"e_1_2_8_27_1","volume-title":"The first year of life","author":"Hardy JB","year":"1979"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/25.3.293"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1077"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS12898J"},{"key":"e_1_2_8_31_1","first-page":"83","article-title":"Clinical eruption of permanent incisors and first molars after maternal smoking in pregnancy","volume":"27","author":"Heikkinen T","year":"1995","journal-title":"Acta Med Auxol"},{"key":"e_1_2_8_32_1","first-page":"473","volume-title":"Dental morphology '98: proceedings of the 11th International Symposium on Dental Morphology","author":"Heikkinen T","year":"1998"},{"key":"e_1_2_8_33_1","first-page":"301","volume-title":"Current trends in dental morphology research","author":"Heikkinen T","year":"2005"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345980770060201"},{"key":"e_1_2_8_35_1","first-page":"11","article-title":"Ranges of normalcy in the eruption of permanent teeth","volume":"16","author":"Hurme VO","year":"1949","journal-title":"J Dent Child"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1677\/JME-08-0122"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511983610"},{"key":"e_1_2_8_38_1","volume-title":"The human dentition before birth","author":"Kraus BS","year":"1965"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20096"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2005.03.002"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.152.3723.778"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330480408"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11900"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(91)90012-T"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(94)90088-4"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1120962300024902"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(60)90049-X"},{"key":"e_1_2_8_48_1","volume-title":"The women and their pregnancies","author":"Niswander KR","year":"1972"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/000163501750157072"},{"key":"e_1_2_8_50_1","first-page":"81","article-title":"Delayed tooth eruption","volume":"1","author":"Peedikayil FZ","year":"2011","journal-title":"Review article"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(02)00080-4"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.10011"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20779"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01067432"},{"key":"e_1_2_8_55_1","first-page":"21","article-title":"Race, genetics and human reproductive strategies","volume":"122","author":"Rushton JP","year":"1996","journal-title":"Genet Soc Gen Psychol Monogr"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81656-7"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20211"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012073601808"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2003.10.031"},{"key":"e_1_2_8_60_1","first-page":"82","volume-title":"The placenta in twin pregnancy","author":"Strong SJ","year":"1967"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-52-1-98"},{"key":"e_1_2_8_62_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2478\/aoj-1981-0001","article-title":"Morphogenetic fields within the dentition","volume":"7","author":"Townsend GC","year":"1981","journal-title":"Aust Orthodont J"},{"key":"e_1_2_8_63_1","first-page":"464","volume-title":"Dental morphology '98: proceedings of the 11th International Symposium on Dental Morphology","author":"Townsend GC","year":"1998"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2005.08.003"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700509"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330490206"}],"container-title":["American Journal of Physical Anthropology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajpa.22298","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajpa.22298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T06:11:03Z","timestamp":1715494263000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajpa.22298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,11]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1002\/ajpa.22298"],"URL":"https:\/\/doi.org\/10.1002\/ajpa.22298","archive":["Portico"],"relation":{},"ISSN":["0002-9483","1096-8644"],"issn-type":[{"value":"0002-9483","type":"print"},{"value":"1096-8644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,11]]}}}