{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:03:42Z","timestamp":1792098222485,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Paleodiet research traditionally interprets differences in collagen isotopic compositions (\u03b4\n                    <jats:sup>13<\/jats:sup>\n                    C, \u03b4\n                    <jats:sup>15<\/jats:sup>\n                    N) as indicators of dietary distinction even though physiological processes likely play some role in creating variation. This research investigates the degree to which bone collagen \u03b4\n                    <jats:sup>13<\/jats:sup>\n                    C and \u03b4\n                    <jats:sup>15<\/jats:sup>\n                    N values normally vary within the skeleton and examines the influence of several diseases common to ancient populations on these isotopic compositions. The samples derive from two medieval German cemeteries and one Swiss reference collection and include examples of metabolic disease (rickets\/osteomalacia), degenerative joint disease (osteoarthritis), trauma (fracture), infection (osteomyelitis), and inflammation (periostitis). A separate subset of visibly nonpathological skeletal elements from the German collections established normal intraindividual variation. For each disease type, tests compared bone lesion samples to those near and distant to the lesions sites. Results show that normal (nonpathological) skeletons exhibit limited intraskeletal variation in carbon\u2010 and nitrogen\u2010isotope ratios, suggesting that sampling of distinct elements is appropriate for paleodiet studies. In contrast, individuals with osteomyelitis, healed fractures, and osteoarthritis exhibit significant intraskeletal differences in isotope values, depending on whether one is comparing lesions to near or to distant sites. Skeletons with periostitis result in significant intraskeletal differences in nitrogen isotope values only, while those with rickets\/osteomalacia do not exhibit significant intraskeletal differences. Based on these results, we suggest that paleodiet researchers avoid sampling collagen at or close to lesion sites because the isotope values may be reflecting both altered metabolic processes and differences in diet relative to others in the population. Am J Phys Anthropol 153:598\u2013604, 2014. \u00a9 2013 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajpa.22459","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T02:44:44Z","timestamp":1388371484000},"page":"598-604","source":"Crossref","is-referenced-by-count":111,"title":["Intraskeletal isotopic compositions (\u03b4\n                    <sup>13<\/sup>\n                    C, \u03b4\n                    <sup>15<\/sup>\n                    N) of bone collagen: Nonpathological and pathological variation"],"prefix":"10.1002","volume":"153","author":[{"given":"Karyn C.","family":"Olsen","sequence":"first","affiliation":[{"name":"Department of Anthropology The University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine D.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Anthropology The University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred J.","family":"Longstaffe","sequence":"additional","affiliation":[{"name":"Department of Earth Sciences The University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"von Heyking","sequence":"additional","affiliation":[{"name":"Department of Biology I, Biodiversity\/Anthropology Ludwig\u2010Maximilians\u2010University, Biocenter Martinsried Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"McGlynn","sequence":"additional","affiliation":[{"name":"State Collection for Anthropology and Palaeoanatomy Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Grupe","sequence":"additional","affiliation":[{"name":"Department of Biology I, Biodiversity\/Anthropology Ludwig\u2010Maximilians\u2010University, Biocenter Martinsried Munich Germany"},{"name":"State Collection for Anthropology and Palaeoanatomy Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"R\u00fchli","sequence":"additional","affiliation":[{"name":"Centre for Evolutionary Medicine, Institute of Anatomy, University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-02894-0_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00329.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4403(83)90073-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/317806a0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(78)90199-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/appe.1997.0116"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1708"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2090"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101631"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4403(91)90066-X"},{"key":"e_1_2_7_12_1","first-page":"357","volume-title":"Biochemistry","author":"Harvey RA","year":"2011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20598"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/1369361"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-863-3:001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1945.01230030172006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/oa.658"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050246"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20051685"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jas.2006.12.020"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1212(199909\/10)9:5<316::AID-OA500>3.0.CO;2-D"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4403(89)90024-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/30.8.1301"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/ajcn\/34.6.1087","article-title":"Contribution of skeletal muscle protein in elevated rates of whole body protein catabolism in trauma patients","volume":"34","author":"Long CL","year":"1981","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/230241a0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(86)90068-2"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0168-9622(87)90064-9","article-title":"Isotopic fractionation of nitrogen and carbon in the synthesis of amino acids by microorganisms","volume":"65","author":"Macko SA","year":"1987","journal-title":"Chem Geol"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2477"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/036354658501300202"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(84)90204-7"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80083-7"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.3.593"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.22140"},{"key":"e_1_2_7_34_1","first-page":"142","volume-title":"Bone histomorphometry: techniques and interpretations","author":"Parfitt AM","year":"1983"},{"key":"e_1_2_7_35_1","first-page":"324","volume-title":"Clinical nutrition","author":"Paton NI","year":"2005"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/30.8.1254"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.10219"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00764.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-7037(84)90091-7"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330340613"},{"key":"e_1_2_7_41_1","first-page":"725","volume-title":"Handbook of environmental isotope geochemistry: advances in isotope geochemistry","author":"Schwarcz HP","year":"2011"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-863-3:021"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002185960004853X"},{"key":"e_1_2_7_44_1","volume-title":"Unpublished Master's thesis","author":"Strange MR","year":"2006"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-88-470-0552-5_18"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.11.006"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/jasc.1998.0385"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2004.04.017"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-2025-y"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02820136"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-1458-8_9"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444345940.ch27"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8644(199706)103:2<185::AID-AJPA11>3.0.CO;2-#"},{"key":"e_1_2_7_54_1","volume-title":"Unpublished Doctoral thesis","author":"Williams LJ","year":"2008"},{"key":"e_1_2_7_55_1","first-page":"213","volume-title":"Infection: the physiologic and metabolic responses of the host","author":"Wolfe RR","year":"1981"},{"key":"e_1_2_7_56_1","first-page":"211","volume-title":"Methods for investigation of amino acid and protein metabolism","author":"Yu Y\u2010M","year":"1999"}],"container-title":["American Journal of Physical Anthropology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajpa.22459","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajpa.22459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T12:22:58Z","timestamp":1696594978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajpa.22459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,30]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/ajpa.22459"],"URL":"https:\/\/doi.org\/10.1002\/ajpa.22459","archive":["Portico"],"relation":{},"ISSN":["0002-9483","1096-8644"],"issn-type":[{"value":"0002-9483","type":"print"},{"value":"1096-8644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,30]]}}}