{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:03:47Z","timestamp":1792098227028,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000155","name":"Social Sciences and Humanities Research Council of Canada","doi-asserted-by":"publisher","award":["766-2011-0294"],"award-info":[{"award-number":["766-2011-0294"]}],"id":[{"id":"10.13039\/501100000155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Variation in \u03b4\n                    <jats:sup>13<\/jats:sup>\n                    C and \u03b4\n                    <jats:sup>15<\/jats:sup>\n                    N values can be assessed to understand not only diet, but also the influence of physiological factors on an individual. The metabolic balance of an individual can impact isotopic signals in tissues that are forming during the periods of metabolic stress. Fluctuating \u03b4\n                    <jats:sup>15<\/jats:sup>\n                    N values are associated with physiological stressors that alter an individual's metabolism such as infection, injury, or pregnancy. This study examines variation in \u03b4\n                    <jats:sup>13<\/jats:sup>\n                    C and \u03b4\n                    <jats:sup>15<\/jats:sup>\n                    N values along sequentially segmented hair in both modern and archaeological individuals. Subjects with an observable skeletal pathology, known chronic illness, or evidence of pregnancy were compared with controls exhibiting no evidence of physiological stress. The results on hair samples from individuals from 19\n                    <jats:sup>th<\/jats:sup>\n                    century Belleville, Ontario, four modern cadavers (two with cancer and two sudden deaths), and two living pregnant women indicate that \u03b4\n                    <jats:sup>15<\/jats:sup>\n                    N values are approximately 1\u2030 higher in individuals with a pathological condition (e.g., infection, fracture, or cancer) and are 1\u2030 lower during pregnancy, whereas \u03b4\n                    <jats:sup>13<\/jats:sup>\n                    C values show less variability. Higher nitrogen values may represent the recycling of nitrogen derived from the breakdown of existing proteins in the body (catabolism), whereas lower \u03b4\n                    <jats:sup>15<\/jats:sup>\n                    N values are related to increased utilization of dietary and urea nitrogen for tissue synthesis during pregnancy. These findings suggest that short\u2010term fluctuations of \u03b4\n                    <jats:sup>15<\/jats:sup>\n                    N values may be the result of changes in an individual's metabolic balance, and that metabolic imbalance poses a confounding factor to ancient dietary studies when using rapidly growing tissues such as hair. Am J Phys Anthropol 157:374\u2013388, 2015. \u00a9 2015 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajpa.22722","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T23:48:47Z","timestamp":1424821727000},"page":"374-388","source":"Crossref","is-referenced-by-count":84,"title":["You are not what you eat during physiological stress: Isotopic evaluation of human hair"],"prefix":"10.1002","volume":"157","author":[{"given":"Lori","family":"D'Ortenzio","sequence":"first","affiliation":[{"name":"Department of Anthropology McMaster University Hamilton ON Canada L8S 4L9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Brickley","sequence":"additional","affiliation":[{"name":"Department of Anthropology McMaster University Hamilton ON Canada L8S 4L9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Schwarcz","sequence":"additional","affiliation":[{"name":"Department of Anthropology McMaster University Hamilton ON Canada L8S 4L9"},{"name":"School of Geography &amp; Earth Sciences McMaster University Hamilton ON Canada L8S 4L9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Prowse","sequence":"additional","affiliation":[{"name":"Department of Anthropology McMaster University Hamilton ON Canada L8S 4L9"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.26.020175.000301"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/30.8.1236"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2700.62099"},{"key":"e_1_2_7_5_1","first-page":"114","article-title":"Nitrogen balance after injuries","volume":"17","author":"Bull JP","year":"1958","journal-title":"J Clin Nutr"},{"key":"e_1_2_7_6_1","first-page":"193","volume-title":"Nutrition and metabolism in patient care","author":"Cahill GF","year":"1988"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200209000-00008"},{"key":"e_1_2_7_8_1","first-page":"2","article-title":"The biology of fracture healing: an overview for clinicians. 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