{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:05:24Z","timestamp":1775610324024,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003336","name":"Bulgarian National Science Fund","doi-asserted-by":"publisher","award":["DN01\/15\u201020.12.2016"],"award-info":[{"award-number":["DN01\/15\u201020.12.2016"]}],"id":[{"id":"10.13039\/501100003336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The sagittal suture (SS) is assumed to be an initial site for the commencement of cranial suture closure as well as the most frequent spot of isolated craniosynostosis. The present study aimed to inspect the reorganization of the SS at the microlevel to assess the relation between its closure and aging and to establish whether it could be used as a reliable indicator in age\u2010at\u2010death prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The SS was investigated in 68 dry contemporary adult male skulls of known age\u2010at\u2010death. An additional series of 20 skulls was used for verification. The skulls were scanned using a micro\u2010computed tomography system. The SS closure degree was assessed along the three bone layers on cross\u2010sectional tomograms by using a scoring scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the entirely open SS, the bone edges consist of compact bone and are widely separated. With SS maturation, the bone edges come into contact, and the remodeling process leads to a decrease in the sutural area and bone homogenization across all three layers. SS closure is an irregular process roughly related to aging, beginning in the early 20s, reaching its peak at about 30\u2009years of age and abating in the late 40s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Although related to aging, SS closure is not a simple function of it. Rather, the underlying factors inducing and managing this process are multifaceted and complex. Although the etiology of SS maturation remains unclear, it is reasonable to use SS closure cautiously and only as a supportive method for age prediction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajpa.23810","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T14:42:05Z","timestamp":1552056125000},"page":"78-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sagittal suture maturation: Morphological reorganization, relation to aging, and reliability as an age\u2010at\u2010death indicator"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-0707","authenticated-orcid":false,"given":"Silviya","family":"Nikolova","sequence":"first","affiliation":[{"name":"Department of Anthropology and Anatomy, Institute of Experimental Morphology, Pathology and Anthropology with Museum Bulgarian Academy of Sciences  Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Toneva","sequence":"additional","affiliation":[{"name":"Department of Anthropology and Anatomy, Institute of Experimental Morphology, Pathology and Anthropology with Museum Bulgarian Academy of Sciences  Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Georgiev","sequence":"additional","affiliation":[{"name":"Department of Scientific Computations, Institute of Information and Communication Technologies Bulgarian Academy of Sciences  Sofia Bulgaria"},{"name":"Department of Mathematical Modeling and Numerical Analysis, Institute of Mathematics and Informatics Bulgarian Academy of Sciences  Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai","family":"Lazarov","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology Medical University of Sofia  Sofia Bulgaria"},{"name":"Department of Synaptic Signaling and Communications, Institute of Neurobiology Bulgarian Academy of Sciences  Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"History of human life span and mortality","author":"Acs\u00e1di G. Y.","year":"1970"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.scs.0000230019.46896.b0"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"495","article-title":"On the premature obliteration of sutures in the human skull","volume":"17","author":"Bolk L.","year":"1915","journal-title":"Developmental Dynamics"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330130403"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000120908"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20322"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20055"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-013-0883-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470507"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.20218"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM189004241221701"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040103"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.227"},{"key":"e_1_2_8_15_1","first-page":"373","article-title":"Untersuchungen \u00fcber die Normale Obliteration des Sch\u00e4deln\u00e4hte","volume":"9","author":"Frederic J.","year":"1906","journal-title":"Zeitschrift f\u00fcr Morphologie und Anthropologie"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.1.0053"},{"key":"e_1_2_8_17_1","volume-title":"Irr: various coefficients of interrater reliability and agreement","author":"Gamer M.","year":"2012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/13158"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2009.01.091"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000143860"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000115031"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(199707)103:3<393::AID-AJPA8>3.0.CO;2-R"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.235"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/oa.1390040304"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100080608"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.10260"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208101203"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091100109"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330680106"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091270307"},{"key":"e_1_2_8_33_1","first-page":"22","article-title":"Functional anatomy of cranial synostosis","volume":"1","author":"Moss M. L.","year":"1975","journal-title":"Child's Brain"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1537\/ase.160530"},{"key":"e_1_2_8_35_1","first-page":"125","article-title":"A CT\u2010study of the cranial suture morphology and its reorganization during the obliteration","volume":"41","author":"Nikolova S.","year":"2017","journal-title":"Collegium Antropologicum"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.23375"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jofri.2018.02.001"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2010.04.006"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1073>3.0.CO;2-F"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199810000-00010"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-2484(84)80065-2"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.10.PEDS09138"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.06.002"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2000_037_0005_antftq_2.3.co_2"},{"key":"e_1_2_8_45_1","first-page":"257","article-title":"Computed tomographic assisted study of morphological changes in the sutural areas as resulting from obliteration","volume":"61","author":"Skrzat J.","year":"2002","journal-title":"Folia Morphologica (Warsz)"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(80)90174-7"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20002"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330070320"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330080103"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1597\/06-122.1"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199707000-00005"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2009.10.012"}],"container-title":["American Journal of Physical Anthropology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajpa.23810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajpa.23810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajpa.23810","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajpa.23810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T10:30:56Z","timestamp":1694341856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajpa.23810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,8]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/ajpa.23810"],"URL":"https:\/\/doi.org\/10.1002\/ajpa.23810","archive":["Portico"],"relation":{},"ISSN":["0002-9483","1096-8644"],"issn-type":[{"value":"0002-9483","type":"print"},{"value":"1096-8644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,8]]},"assertion":[{"value":"2018-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}