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This high volatility led to increased mobility and migration due to new labor and economic opportunities, as evidenced by documentary and stable isotope data. This study uses ancient DNA (aDNA) isolated from skeletal remains to examine whether evidence for large\u2010scale population movement can be gleaned from the complete mitochondrial genomes of 264 medieval individuals from England (London) and Denmark.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Using a novel library\u2010conserving approach to targeted capture, we recovered 264 full mitochondrial genomes from the petrous portion of the temporal bones and teeth and compared genetic diversity across the medieval period within and between English (London) and Danish populations and with contemporary populations through population pairwise \u03a6<jats:sub>ST<\/jats:sub>analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We find no evidence of significant differences in genetic diversity spatially or temporally in our dataset, yet there is a high degree of haplotype diversity in our medieval samples with little exact sequence sharing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The mitochondrial genomes of both medieval Londoners and medieval Danes suggest high mitochondrial diversity before, during and after the Black Death. While our mitochondrial genomic data lack geographically correlated signals, these data could be the result of high, continual female migration before and after the Black Death or may simply indicate a large female effective population size unaffected by the upheaval of the medieval period. Either scenario suggests a genetic resiliency in areas of northwestern medieval Europe.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajpa.23820","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T16:52:18Z","timestamp":1554828738000},"page":"240-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Genetic resiliency and the Black Death: No apparent loss of mitogenomic diversity due to the Black Death in medieval London and Denmark"],"prefix":"10.1002","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6521-8516","authenticated-orcid":false,"given":"Jennifer","family":"Klunk","sequence":"first","affiliation":[{"name":"McMaster Ancient DNA Centre McMaster University Hamilton Ontario Canada"},{"name":"Department of Biology McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana T.","family":"Duggan","sequence":"additional","affiliation":[{"name":"McMaster Ancient DNA Centre McMaster University Hamilton Ontario Canada"},{"name":"Department of Anthropology McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Redfern","sequence":"additional","affiliation":[{"name":"Center for Human Bioarchaeology Museum of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Gamble","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of Manitoba Winnipeg Manitoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper L.","family":"Boldsen","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Unit of Anthropology (ADBOU) University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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