{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:19:03Z","timestamp":1773080343449,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009635","name":"Wildlife Conservation Society Argentina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In 2007\u20132009, a major yellow fever virus (YFV) outbreak in Northern Argentina decimated the local howler monkey (Alouatta) population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether the surviving howler monkeys possess advantageous genetic variants inherited from monkeys alive prior to the YFV outbreak, we explored the relationship between Toll\u2010like receptor (TLR) 7 and TLR8 gene variation and YFV susceptibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used samples from Alouatta individuals in Misiones, Argentina alive before the YFV outbreak, individuals that died during the outbreak, and individuals that survived the outbreak and are alive today. We measured genetic divergence between Alouatta YFV exposure groups and evaluated Alouatta\u2010specific substitutions for functional consequences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We did not find different allele frequencies in the post\u2010YFV exposure Alouatta group compared to the pre\u2010exposure group. We identified three nonsynonymous variants in TLR7 in Alouatta guariba clamitans. Two of these substitutions are under positive selection in functionally important regions of the gene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>Our results did not indicate that surviving howler monkey spossess advantageous genetic variants at greater frequency than those alive before the YFV outbreak. However, the positively selected unique coding differences in A. guariba clamitans are in the region important in pathogen detection which may affect YFV resistance. Morework is necessary to fully explore this hypothesis<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajpa.24086","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T07:27:41Z","timestamp":1593070061000},"page":"50-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Positively selected variants in functionally important regions of\n                    <scp>TLR7<\/scp>\n                    in\n                    <i>Alouatta guariba clamitans<\/i>\n                    with yellow fever virus exposure in Northern Argentina"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-5403","authenticated-orcid":false,"given":"Nicole S.","family":"Torosin","sequence":"first","affiliation":[{"name":"Department of Anthropology University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy H.","family":"Webster","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hern\u00e1n","family":"Argibay","sequence":"additional","affiliation":[{"name":"Instituto de Ecolog\u00eda, Gen\u00e9tica y Evoluci\u00f3n de Buenos Aires (IEGEBA\u2010CONICET), Intendente G\u00fciraldes 2160 \u2010 Ciudad Universitaria (C1428EGA) Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candelaria","family":"Sanchez Fernandez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular Aplicada, Facultad de Ciencias Exactas, Qu\u00edmicas y Naturales, Universidad Nacional de Misiones Posadas Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hebe","family":"Ferreyra","sequence":"additional","affiliation":[{"name":"Global Health Program, Wildlife Conservation Society Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Uhart","sequence":"additional","affiliation":[{"name":"One Health Institute, School of Veterinary Medicine, University of California, Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Agostini","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Subtropical (IBS), Universidad Nacional de Misiones (UNaM), Consejo Nacional de Investigaciones Cient\u00edfcas y T\u00e9cnicas (CONICET) Puerto Iguaz\u00fa Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie A.","family":"Knapp","sequence":"additional","affiliation":[{"name":"Department of Anthropology University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx299"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/194008291400700107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10329-008-0106-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10764-010-9390-x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10764-015-9821-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10329-007-0039-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24174"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2006.10.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.52.110405.091454"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.12.010"},{"key":"e_1_2_7_15_1","first-page":"38","volume-title":"Estudio sobre la fiebre amarilla selvatica en la republica Argentina","author":"Bejarano J. 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